ArticleFrontiers in neurology2025
Cognitive impairment and brain atrophy in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a normative analysis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Working Memory Impairment Induced by Chemotherapy-A Narrative Review.Brain sciences · 2026Review
- Evidence-Based Strategies for Addressing Cancer- and Treatment-Related Cognitive Impairment: A Review.Biomolecules & therapeutics · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Cancer-related cognitive impairment (CRCI) can impact daily-life functioning of people with aggressive lymphoma. While many studies have examined the neural substrates implicated in CRCI, most have used group-based analyses, which may mask individual differences. In the present study, we used normative analysis to examine longitudinal changes in cognitive functioning and brain morphology at the level of the individual patient. Methods: Nine participants with newly diagnosed aggressive lymphoma underwent neuropsychological assessment and anatomical MR before and 6-8 weeks after chemotherapy. Cognitive test scores were converted to Results: Analyses revealed substantial between-subject variability over time and across outcome measures. Cognitive impairments in executive function and verbal memory were identified in three participants before and/or after chemotherapy. CentileBrain results showed seven participants had infranormal cortical thickness and/or surface area in the SFG at one or both time points, and one patient had infranormal values in the ACC. No participants exhibited supranormal values in either region at any time point. Conclusion: Our findings provide a valuable foundation for developing more personalised interventions tailored to the specific cognitive and neural profiles of lymphoma survivors, paving the way for improved clinical care to alleviate and mitigate the impact of CRCI on long-term quality of life. Clinical trial registration: https://www.anzctr.org.au/, identifier ACTRN12619001649101.
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