Evidence map›Paper›PMID 41044113›Full record

ArticleScientific reports2025

The effect of iodine supplementation on oocyte apoptosis and proliferation in women with diminished ovarian reserve: a pilot study.

Masoumeh Masoumi, Maryam Bagheri, Sedighe Hantoushzadeh, Mina Jafarabadi, Masoumeh Dehghan Tarazjani, Fedyeh Haghollahi, Mehdi Hedayati, Farnush Naseri, Pantea Nazeri

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Masoumeh MasoumiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran. masomeh_masomi@yahoo.com.ORCID http://orcid.org/0000-0003-1987-3410
Maryam BagheriVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.
Sedighe HantoushzadehVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.
Mina JafarabadiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.
Masoumeh Dehghan TarazjaniInfertility Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Fedyeh HaghollahiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, P.O. Box: 1419733141, Tehran, Iran.
Mehdi HedayatiCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farnush NaseriMedical Genetics Ward, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Pantea NazeriBreastfeeding Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran. nazeri.pantea@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iodine, an essential trace element, may play a role in reproductive health through its extrathyroidal actions. This study aimed to investigate the effects of iodine supplementation on oocyte apoptosis and proliferation in women with diminished ovarian reserve. A quasi-experimental study was conducted on ten women undergoing two cycles of ovarian stimulation. In the first cycle, they followed the standard protocol, while in the second, they received a daily 150 µg iodine supplement for two months. Urinary iodine levels, cumulus cell apoptosis and necrosis, and PCNA expression were evaluated before and after supplementation. We found that iodine supplementation significantly improved women's iodine status, increasing it from borderline sufficiency to optimal levels. This improvement was accompanied by a significant increase in the number of metaphase II oocytes. Following iodine supplementation, we observed a marked increase in cumulus cell viability and a reduction in both early and late apoptosis. Additionally, the expression of PCNA was upregulated, showing a positive association with the percentage of live cells and a reduction in total apoptosis. These findings suggest that iodine supplementation could be a promising therapeutic strategy for improving oocyte quality and enhancing fertility outcomes, particularly in women with diminished ovarian reserve.

Indexed as

ApoptosisDietary SupplementsIodineOocytesOvarian ReserveAdultCell ProliferationCumulus CellsFemaleHumansOvulation InductionPilot ProjectsProliferating Cell Nuclear AntigenIodineProliferating Cell Nuclear AntigenApoptosisDiminished ovarian reserveIodine supplementOocyteProliferation

Identifiers

PMID41044113
PMCPMC12494958

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.