Trial reportInternational journal of obesity (2005)2025
Effect of weight loss through dietary interventions on cardiometabolic health in older adults.
Trial report in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02817074 (MIND Diet Intervention to Prevent Alzheimer's Disease), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MIND Diet Intervention to Prevent Alzheimer's Disease
Who cites it
4 citing papers in PubMed.
- Changes in food cravings, dietary quality, body composition, and dietary intake during GLP-1 receptor agonist therapy: The CRAVE study.Obesity pillars · 2026Article
- Dietary patterns and protein density associations with fat-free mass in a cross-sectional analysis of rural Iranian adults with overweight and obesity.Scientific reports · 2026Article
- Evaluation of nutritional interventions and their impact on metabolic syndrome risk markers in older adults.Frontiers in nutrition · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundWith the increasing prevalence of obesity and its negative consequences on health, weight management emerges as a priority for public health, especially in older adults, in whom obesity is linked to increased risks of chronic diseases such as cardiovascular disease. We performed a study investigating the association of intentional weight loss through dietary intervention on cardiometabolic health among older adults participating in the MIND trial.
methodsThe MIND trial enrolled overweight individuals aged 65-84 who self-reported a suboptimal diet. Participants were randomized to the MIND or a control diet for 3 years; both diets promoted weight loss through mild caloric restriction (250 kcal). Of 604 individuals enrolled in the trial, 518 were included in the analysis. We calculated the percentage of weight loss based on measured weight at the baseline and year 3 and categorized individuals into four groups: no weight loss (e.g., weight gain), <5%, 5-10%, and >10% weight loss. Cardiometabolic health included traditional lipid biomarkers, biomarkers of inflammation, and glycosylated hemoglobin. Linear mixed-effect models were used to evaluate the associations of weight loss with cardiometabolic health.
resultsAt the baseline, mean age was 70 (SD = 4.1) years, 332 (65%) were women, and BMI was 33.8 (SD = 5.9) kg/m2. Compared to people who did not lose weight, those with >10% weight loss significantly improved their biomarkers of cardiometabolic health at the year 3 visit as follows: LDL cholesterol levels decreased by 8.3%, triglycerides by 28.2%, and HDL increased by 12.4%. As for biomarkers of inflammation, GlycA decreased by 7.5%, hs-IL6 by 33.0%, hs-CRP by 59.4%, and adiponectin increased by 53.7%. These improvements in biomarkers of cardiometabolic health did not differ by dietary intervention.
conclusionWeight loss through dietary interventions with mild calorie restriction resulted in favorable changes in cardiometabolic risk factors among older adults with overweight and obesity. CLINICAL TRIAL REGISTRATION NUMBER: NCT02817074.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.