Evidence map›Paper›PMID 41044293›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Ring-fused chlorin-enhanced photodynamic therapy for effective cell death induction in endometrial cancer.

Beatriz Serambeque, Gabriela Correia-Barros, Sofia Pinto Lopes, Nelson A M Pereira, Raquel Alves, Ana Cristina Gonçalves, João Martins Gama, Francisco Caramelo, Ricardo Teixo, Catarina Cerdeira and 7 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Beatriz SerambequeUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal. beatriz.serambeque@student.uc.pt.
Gabriela Correia-BarrosUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal.
Sofia Pinto LopesUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal.
Nelson A M PereiraUniv Coimbra, Coimbra Chemistry Centre - Institute of Molecular Sciences and Department of Chemistry, Coimbra, Portugal.
Raquel AlvesUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Laboratory of Oncobiology and Hematology (LOH) and University Clinics of Hematology and Oncology, Faculty of Medicine, Coimbra, Portugal.
Ana Cristina GonçalvesUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Laboratory of Oncobiology and Hematology (LOH) and University Clinics of Hematology and Oncology, Faculty of Medicine, Coimbra, Portugal.
João Martins GamaDepartment of Pathology, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Francisco CarameloClinical Academic Centre of Coimbra (CACC), Coimbra, Portugal.
Ricardo TeixoUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal.
Catarina CerdeiraPolytechnic University of Coimbra, ESTESC - Coimbra Health School, Coimbra, Portugal.
Fátima SilvaPolytechnic University of Coimbra, ESTESC - Coimbra Health School, Coimbra, Portugal.
Augusta CiprianoDepartment of Pathology, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Marta PineiroUniv Coimbra, Coimbra Chemistry Centre - Institute of Molecular Sciences and Department of Chemistry, Coimbra, Portugal.
Maria Filomena BotelhoUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal.
Teresa M V D Pinho E MeloUniv Coimbra, Coimbra Chemistry Centre - Institute of Molecular Sciences and Department of Chemistry, Coimbra, Portugal.
Maria João CarvalhoUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics and Universitary Clinic of Gynecology, Faculty of Medicine, Coimbra, Portugal.
Mafalda LaranjoUniv Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB); Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, Coimbra, Portugal. mafaldalaranjo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of photodynamic therapy based on stable 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins (PX) was explored in endometrial cancer. In vitro, photocytotoxicity of three derivatives of ring-fused chlorins (dihydroxymethyl, dicarboxylic acid, and dimethyl ester moieties) was evaluated in three endometrial cancer cell lines, ECC-1, RL95-2, and HEC-1-A. A comprehensive assessment of chlorins-induced intracellular production of reactive oxygen species, viability and PDT-induced types of cell death, influence on the cell cycle, intracellular localisation, and the protein expression of aldehyde dehydrogenase after photodynamic treatment was carried out. The photodynamic effect of the dihydroxymethyl derivative was then evaluated in vivo by monitoring tumour volume and performing histological and immunohistochemical analyses of the tumours. The dihydroxymethyl and dicarboxylic acid derivatives were the most active photosensitisers, presenting IC

Indexed as

Antineoplastic AgentsEndometrial NeoplasmsPhotochemotherapyPhotosensitizing AgentsPorphyrinsAnimalsApoptosisCell DeathCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorFemaleHumansMiceMolecular StructureReactive Oxygen SpeciesAntineoplastic AgentschlorinPhotosensitizing AgentsPorphyrinsReactive Oxygen SpeciesChlorinsEndometrial cancerPhotodynamic therapyPhotosensitiserReactive oxygen species

Identifiers

PMID41044293

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.