Evidence map›Paper›PMID 41044357›Full record

ArticleCommunications chemistry2025

A dual fluorescent-Raman bioorthogonal probe for specific biosynthetic labeling of intracellular gangliosides.

Mana Mohan Mukherjee, Matthew D Watson, Devin Biesbrock, Lara K Abramowitz, Steven K Drake, Jennifer C Lee, John A Hanover

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PerturbingCells · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mana Mohan MukherjeeLaboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4271-8171
Matthew D WatsonLaboratory of Protein Conformation and Dynamics, NHLBI, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0350-6491
Devin BiesbrockLaboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD, USA.
Lara K AbramowitzLaboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD, USA.
Steven K DrakeCritical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1172-6793
Jennifer C LeeLaboratory of Protein Conformation and Dynamics, NHLBI, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0506-8349
John A HanoverLaboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD, USA. johnh@bdg8.niddk.nih.gov.ORCID http://orcid.org/0000-0002-3154-9878

Funding

Raman Spectroscopic Studies of AmyloidsZIAHL006236 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEE, JENNIFER · 2018 to 2025
$5.5M
Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of DiseaseZ01DK060101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANOVER, JOHN A. · 2007 to 2008
$744k
Intramural NIH HHS Z01 DK060101Intramural NIH HHS ZIA HL006236U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) ZIA HL006236-06
6 · The paper itself

Abstract

Gangliosides are sialic acid-containing glycosphingolipids integral to the cell membrane, and they are particularly abundant in the nervous system. Aberrant ganglioside metabolism contributes to pathological conditions, including neurodegenerative diseases, lysosomal storage disorders, and cancer. A critical precursor for sialic acid biosynthesis is N-acetyl-D-mannosamine (ManNAc), which can be epimerized from the corresponding UDP-GlcNAc or exogenously supplied through ManNAc derivatives. Currently, tools to visualize and detect gangliosides are very limited and non-specific. Here, we describe a dual fluorescent and Raman-active ManNAlk derivative, phenanthrene-9-Pr

Identifiers

PMID41044357
PMCPMC12494992

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.