Evidence map›Paper›PMID 41044653›Full record

Trial reportClinical epigenetics2025

Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.

Lyndsey E Shorey-Kendrick, Cindy T McEvoy, Kristin Milner, Julia Harris, Julie Brownsberger, Robert S Tepper, Byung Park, Lina Gao, Annette Vu, Cynthia D Morris and 3 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01723696 phase2 / phase3completednot on this map

Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function

TypeinterventionalSponsorOregon Health and Science UniversityRan2012 to 2017Enrolled252ConditionsPulmonary Function, Newborn, Abnormal, Infant Wheeze, In-utero NicotineArmsVitamin C +prenatal vitamin, Placebo tablet+prenatal vitamin
NCT03203603 completednot on this map

Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Follow-up of a Randomized Trial

TypeobservationalSponsorOregon Health and Science UniversityRan2017 to 2024Enrolled242ConditionsAsthma, Pulmonary Function, Wheezing, In Utero NicotineArmsNo active intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lyndsey E Shorey-KendrickDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR, 97006, USA. shorey@ohsu.edu.
Cindy T McEvoyDepartment of Pediatrics, Pape Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA.
Kristin MilnerDepartment of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Julia HarrisDepartment of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Julie BrownsbergerDepartment of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Robert S TepperDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Byung ParkBiostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Lina GaoBiostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Annette VuOregon Clinical & Translational Research Institute, Oregon Health & Science, Portland, OR, USA.
Cynthia D MorrisOregon Clinical & Translational Research Institute, Oregon Health & Science, Portland, OR, USA.
Emma E ThompsonDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Eliot R SpindelDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR, 97006, USA.

Funding

Support for National Primate Research CenterP51OD011092 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$13.7M
Vitamin C to Decrease Effects of Smoking during Pregnancy on Offspring Airway Function, Airway Size, and Epigenetic Correlates: VCSIP cohort follow-up through 10 Years of AgeR01HL162951 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$1.8M
Continued follow-up of the Vitamin C and Smoking in Pregnancy (VCSIP) cohorts through the ECHO consortium, focus on Echo-wide protocols, respiratory outcomes, airway function, and epigenetic changesUH3OD023288 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$1.0M
National Heart, Lung, and Blood Institute,United States R01 HL 105460NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1TR000128NHLBI NIH HHS R01 HL105447NHLBI NIH HHS R01 HL105460NHLBI NIH HHS R01 HL162951NIH HHS P51 OD011092NIH HHS P51 OD011092565NIH HHS UH3 OD023288
6 · The paper itself

Abstract

backgroundWe previously reported improved respiratory outcomes in babies born to pregnant smokers supplemented with vitamin C (500 mg/day) versus placebo in a randomized clinical trial. Improved respiratory outcomes persisted to 5 years of age and were associated with buccal DNA methylation (DNAm) measured using the InfiniumMethylationEPIC array. The objective of this study was to examine associations of vitamin C treatment and lung function with buccal DNAm using a custom-content Asthma&Allergy array enriched for asthma and allergy loci likely to have a functional impact on gene expression.

resultsWe profiled DNAm at 36,999 CpGs in loci previously associated with asthma or allergic diseases using custom-content Asthma&Allergy arrays in 137 subjects (65 placebo; 72 vitamin C) with pulmonary function testing (PFT) at the 5-year visit in the "Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function" (VCSIP) double-blind, placebo-controlled randomized clinical trial. We examined the association of buccal DNAm with (1) vitamin C treatment vs placebo, (2) forced expiratory flow between 25 and 75% of expired volume (FEF

conclusionsOur study revealed association of in utero vitamin C supplementation and childhood lung function with DNAm at novel loci, providing additional insight toward potential mechanisms for the persistent effects of vitamin C supplementation to pregnant smokers. CLINICAL

trial registrationClinicalTrials.gov, NCT01723696 (Registered on November 6, 2011) and NCT03203603 (Registered on March 28, 2017).

Indexed as

Ascorbic AcidAsthmaDNA MethylationHypersensitivityAdultChild, PreschoolCpG IslandsDietary SupplementsDouble-Blind MethodFemaleHumansMalePregnancyPrenatal Exposure Delayed EffectsRespiratory Function TestsSmokersAscorbic AcidAirwayAllergyAsthmaDNA methylationLung functionMediationNicotineSmokingVitamin CWheeze

Identifiers

PMID41044653
PMCPMC12495669

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.