Evidence map›Paper›PMID 41044672›Full record

ArticleHereditas2025

CircRNA-14052 promotes breast cancer progression via miR-214-3p/IKBKB pathway.

Donghai Li, Zhiying Zhang, Yan Cui, Jiaxin Sun, Wenyuan Wei, Shaofeng Yang, Rui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Donghai Li *Department of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China.
Zhiying Zhang *Department of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China.
Yan CuiSchool of Humanities Education, Inner Mongolia Medical University, Huhhot, 010000, Inner Mongolia, China.
Jiaxin SunClinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China.
Wenyuan WeiDepartment of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China.
Shaofeng YangDepartment of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China.
Rui ZhangDepartment of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot North Street, Hohhot, 010050, Inner Mongolia, China. zhangrui999999@163.com.

Funding

Inner Mongolia Autonomous Region key research and development and achievement transformation plan project 2023YFSH0039Natural Science Foundation of Inner Mongolia Autonomous Region 2022MS08010
6 · The paper itself

Abstract

objectivesCircular RNAs play crucial regulatory roles in the progression of human diseases. This study aimed to investigate the functional mechanism of circRNA-14,052 in breast cancer progression.

methodsThe biological functions of circRNA-14,052 were assessed using CCK-8, wound healing, flow cytometry assays. The ceRNA regulatory network of circRNA-14,052-miR-214-3p- IKBKB was validated by luciferase reporter assay.

resultsThe levels of circRNA-14,052 were notably elevated, but the levels of miR-214-3p were markedly reduced in breast cancer tissues compared to adjacent non-cancerous tissues. Downregulation of circRNA-14,052 or overexpression of miR-214-3p reduced MCF-7 cell proliferation and triggered cell apoptosis. Mechanically, circRNA-14,052 could elevate IKBKB levels via competitively sponging miR-214-3p. Notably, miR-214-3p inhibition reversed the growth-suppressive effects of circRNA-14,052 silencing. Additionally, circRNA-14,052 knockdown notably reduced IKBKB, IL-6, JAK2 and STAT3 levels in MCF-7 cells; whereas these changes were reversed by miR-214-3p deficiency. Furthermore, deficiency of circRNA-14,052 reduced xenograft tumor growth in vivo through targeting miR-214-3p/IKBKB/IL-6/JAK2/STAT3 axis.

conclusionCollectively, our results showed that circRNA-14,052 promotes breast cancer progression via the miR-214-3p/IKBKB axis. Targeting this molecular axis may represent a promising therapeutic strategy for breast cancer treatment.

Indexed as

Breast NeoplasmsI-kappa B KinaseMicroRNAsRNA, CircularAnimalsApoptosisCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansJanus Kinase 2MCF-7 CellsMiceMice, Inbred BALB CI-kappa B KinaseIKBKB protein, humanJanus Kinase 2MicroRNAsMIRN214 microRNA, humanRNA, CircularSTAT3 Transcription FactorBreast cancerCircRNAcircRNA-14052IKBKBJAK2-STAT3miR-214-3p

Identifiers

PMID41044672
PMCPMC12495841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.