ArticleAnnals of dermatology2025
Efficacy and Safety of a PTPD-12-Containing Cream on Improvement in Hyperpigmentation: A Randomized, Split-Face Clinical Trial.
Article in Annals of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
Funding
Abstract
backgroundSkin hyperpigmentation is caused by excessive melanin and can result from various factors, including ultraviolet exposure. Pentasodium tetracarboxymethyl palmitoyl dipeptide-12 (PTPD-12), an autophagy-inducing peptide, has shown potential in regulating melanogenesis in melanocytes and keratinocytes.
objectiveTo evaluate the clinical efficacy and safety of a topical cream containing PTPD-12 in treating facial hyperpigmented disorders.
methodsA prospective, randomized, split-face, controlled clinical trial was conducted over 8 weeks in 21 participants with bilaterally symmetrical facial hyperpigmentation. Subjects applied a PTPD-12-containing cream to one side of the face and a control cream to the other, twice daily. Melanin index (MI), erythema index, The Investigator Global Assessment (IGA) and Patient Global Assessment (PGA), and histological analysis were performed.
resultsTreatment with PTPD-12 cream resulted in a significant reduction in MI from 216.93±45.57 at baseline to 194.69±38.70 at week 8 (mean change, -22.23±15.16;
conclusionPTPD-12 cream significantly reduced melanin levels in facial hyperpigmentation, supporting its potential as a novel, safe, and effective therapeutic option for pigmentary disorders.
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