Evidence map›Paper›PMID 41045346›Full record

ArticleInflammopharmacology2025

Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats.

Ahmed Kouki, Riadh Marrouchi, Abdelaziz Souli, Salwa Bouabdallah, Wafa Ferjani, Pham My-Chan Dang, Amadou Dicko, Jamel El-Benna, Mossadok Ben-Attia

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed KoukiINSERM-U1149, CNRS-ERL8252, Inflammation Research Center, Inflamex Excellence Laboratory, Xavier Bichat Faculty of Medicine, University of Paris-City, 75018, Paris, France.ORCID http://orcid.org/0000-0003-1305-7965
Riadh MarrouchiLaboratory of Venoms and Therapeutic Biomolecules, Pasteur Institute of Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, 1002, Tunis, Tunisia.ORCID http://orcid.org/0000-0003-2311-576X
Abdelaziz SouliEnvironment Biomonitoring Laboratory (LR01/ES14), Sciences Faculty of Bizerte, University of Carthage, Zarzouna, 7021, Bizerte, Tunisia.ORCID http://orcid.org/0000-0002-7891-3526
Salwa BouabdallahEnvironment Biomonitoring Laboratory (LR01/ES14), Sciences Faculty of Bizerte, University of Carthage, Zarzouna, 7021, Bizerte, Tunisia.ORCID http://orcid.org/0000-0002-2458-216X
Wafa FerjaniINSERM-U1149, CNRS-ERL8252, Inflammation Research Center, Inflamex Excellence Laboratory, Xavier Bichat Faculty of Medicine, University of Paris-City, 75018, Paris, France.ORCID http://orcid.org/0000-0002-6256-8668
Pham My-Chan DangINSERM-U1149, CNRS-ERL8252, Inflammation Research Center, Inflamex Excellence Laboratory, Xavier Bichat Faculty of Medicine, University of Paris-City, 75018, Paris, France.ORCID http://orcid.org/0000-0002-7138-1037
Amadou DickoChemistry and Physics Laboratory-Multi-Scale Approach to Complex Media (LCP-A2MC), University of Lorraine, 57078, Metz, France.ORCID http://orcid.org/0000-0001-9173-5085
Jamel El-Benna *INSERM-U1149, CNRS-ERL8252, Inflammation Research Center, Inflamex Excellence Laboratory, Xavier Bichat Faculty of Medicine, University of Paris-City, 75018, Paris, France.ORCID http://orcid.org/0000-0001-5733-216X
Mossadok Ben-Attia *Environment Biomonitoring Laboratory (LR01/ES14), Sciences Faculty of Bizerte, University of Carthage, Zarzouna, 7021, Bizerte, Tunisia. mossadok.benattia@fsb.ucar.tn.ORCID http://orcid.org/0000-0002-5368-4800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pro-inflammatory signaling targets and free radicals contribute to the occurrence of ulcerative colitis (UC). Chemical drugs can reduce the UC, whereas their side effects limit their applications. Currently, plant remedies present a promising field for pharmaceutical research. Our study aims to screen bioactive compounds in the aqueous extract from Silybum marianum seeds (AESS) and determine its effect on neutrophil pro-inflammatory functions and colitis. The phytochemical profile and antioxidant potential of AESS were investigated. Human neutrophils were used to assess AESS cytotoxicity and its effects on oxygen-free radicals using chemiluminescence. The western blot was used to evaluate the degranulation mechanism. Furthermore, azurophilic granules, xanthine-xanthine oxidase (X-XO), and horseradish peroxidase (HRP) were used to examine the AESS effects on myeloperoxidase (MPO), superoxide anion (O₂

Indexed as

Colitis, UlcerativeNeutrophilsPlant ExtractsSeedsSilybum marianumAnimalsAnti-Inflammatory AgentsAntioxidantsDisease Models, AnimalHumansInflammationMalePeroxidaseRatsRats, Sprague-DawleyReactive Oxygen SpeciesAnti-Inflammatory AgentsAntioxidantsPeroxidasePlant ExtractsReactive Oxygen SpeciesInflammatory cytokinesNeutrophil degranulationOxidative stressSilybum marianum seedsUlcerative colitis

Identifiers

PMID41045346

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.