Evidence map›Paper›PMID 41046491›Full record

ArticleMolecular diversity2025

Thiadiazole based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and bioactivity evaluation.

Huan Zhou, Yaxin Wen, Shao-Hua Wang, Yan Liu, Baoqiong Li, Xuetao Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huan ZhouSchool of Pharmacy and Food Engineering and Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China.
Yaxin WenSchool of Pharmacy and Food Engineering and Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China.
Shao-Hua WangSchool of Pharmacy and State Key Laboratory of Applied Organic Chemistry and Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou, 730000, China.
Yan LiuSchool of Pharmacy and State Key Laboratory of Applied Organic Chemistry and Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou, 730000, China. liuyanly@lzu.edu.cn.
Baoqiong LiSchool of Pharmacy and Food Engineering and Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China. libq201406@163.com.
Xuetao XuSchool of Pharmacy and Food Engineering and Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen, 529020, China. wyuchemxxt@126.com.

Funding

Department of Education of Guangdong Province 2021KCXTD044
6 · The paper itself

Abstract

α-Glucosidase has always been one essential target for clinical prevention and treatment of diabetes. To develop effective α-glucosidase inhibitors, twenty-seven thiadiazole based β-carboline derivatives (TC1-TC27) were designed and synthesized by pharmacophore hybridization strategy, and systematically evaluated their inhibitory activity and binding characteristics against α-glucosidase. All synthesized derivatives (TC1-TC27) displayed significant inhibitory activity against α-glucosidase, with TC16 emerging as the most potent compound (IC

Indexed as

InhibitorThiadiazoleα-Glucosidaseβ-Carboline

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.