Evidence map›Paper›PMID 41046622›Full record

ArticleEnvironment international2025

Chemical structure drives developmental toxicity of alkyl-substituted naphthalenes in zebrafish.

Mackenzie L Morshead, Lisa Truong, Steven J Carrell, Richard Scott, Kim A Anderson, Robyn L Tanguay

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mackenzie L MorsheadSinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Lisa TruongSinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Steven J CarrellSinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Richard ScottSinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Kim A AndersonSinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA.
Robyn L TanguaySinnhuber aquatic Research Center, Department of Environmental and Molecular Toxicology and the Oregon State University Superfund Center, Oregon State University, ALS 1007, Corvallis, OR 97331, USA. Electronic address: robyn.tanguay@oregonstate.edu.

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Discovering Chemical Activity Networks-Predicting Bioactivity Based on StructureR35ES031709 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2021 to 2026
$5.2M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R35 ES031709NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

Naphthalene and its alkyl-substituted derivatives are among the most abundant polycyclic aromatic hydrocarbons (PAHs) in environmental and human exposure studies, yet their developmental toxicity and mode of action remain poorly understood due to challenges in testing semi-volatile compounds. This study developed a vial based, high throughput method to effectively assess the activity of naphthalenes and a set of 24 alkyl-substituted naphthalenes. Early life stage zebrafish were exposed to a concentration series of each chemical (0-50 µM) in rotating sealed glass vials to minimize volatilization. Benchmark concentration (BMC

Indexed as

NaphthalenesWater Pollutants, ChemicalZebrafishAnimalsMolecular Docking SimulationPolycyclic Aromatic HydrocarbonsToxicity TestsNaphthalenesPolycyclic Aromatic HydrocarbonsWater Pollutants, ChemicalAlkyl-substituted naphthalenesMolecular dockingNaphthaleneNarcosisPolycyclic aromatic hydrocarbonsTranscriptomicsZebrafish

Identifiers

PMID41046622
PMCPMC12560828

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.