Evidence map›Paper›PMID 41047833›Full record

ArticleCancer2025

Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination.

Julienne E Bower, Arielle Radin, Patricia A Ganz, Michael R Irwin, Steve W Cole, Laura Petersen, Arash Asher, Sara A Hurvitz, Catherine M Crespi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julienne E BowerDepartment of Psychology, The University of California-Los Angeles (UCLA), Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-0813-4444
Arielle RadinBruin Health, Reading, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7100-1081
Patricia A GanzJohnsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-1841-4143
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-1502-8431
Steve W ColeDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, California, USA.
Laura PetersenJohnsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Arash AsherSamuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, California, USA.
Sara A HurvitzDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Catherine M CrespiJohnsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-6150-2181

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
Breast Cancer Research FoundationNCI NIH HHS P30 CA016042NCI NIH HHS R01 CA160427
6 · The paper itself

Abstract

backgroundFatigue is a common and long-lasting side effect of cancer. Although fatigue is a multidimensional symptom, biologic mechanisms of fatigue dimensions have not been identified.

methodsWomen recently diagnosed with early stage breast cancer (n = 192) completed assessments before and after adjuvant therapy and at 6-month, 12-month, and 18-month posttreatment follow-up visits. At each assessment, women completed the Multidimensional Fatigue Symptom Inventory and provided blood for protein markers of inflammation (tumor necrosis factor [TNF] alpha [TNF-α], soluble tumor necrosis factor receptor type II [sTNF-RII], interleukin 6 [IL-6], and C-reactive protein [CRP]). Mixed-effect linear models examined within-person and between-person associations between inflammatory markers and dimensions of fatigue.

resultsAnalyses demonstrated a positive within-person association between general fatigue and TNF-α (b = 1.67; p = .037), sTNF-RII (b = 2.77; p = .002), and IL-6 (b = 0.86; p = .010) when controlling for age, race, education, body mass index, and cancer stage. Similarly, there was a positive within-person association between physical fatigue and TNF-α (b = 1.58; p = .007), sTNF-RII (b = 2.38; p < .001), and CRP (b = 0.43; p = .007). Conversely, there were negative within-person associations between emotional fatigue and TNF-α (b = -1.92; p = .004) and sTNF-RII (b = -2.10; p = .006). General and physical fatigue were positively associated with CRP at the between-person level (b = 0.82, p = .024 for general; b = 0.71; p = .012 for physical). No significant associations between mental fatigue and inflammatory makers were found.

conclusionsThe current findings identified distinct dimensions of fatigue associated with inflammatory activity in women with breast cancer and highlighted individual variability in inflammatory markers as a key predictor of fatigue symptoms.

Indexed as

Breast NeoplasmsFatigueInflammationAdultAgedC-Reactive ProteinFemaleHumansInterleukin-6Longitudinal StudiesMiddle AgedNeoplasm StagingReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphaC-Reactive ProteinInterleukin-6Receptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphabreast cancerfatigueinflammationsymptoms

Identifiers

PMID41047833
PMCPMC12498077

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.