ArticleFrontiers in aging2025
Aging-dependent skin microbiome alterations across body sites in a United Kingdom cohort.
Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Integrated analysis of age-related microbiome and metabolites reveals youth-associated metabolites in young Korean women's skin.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices.International journal of molecular sciences · 2026Review
- Cosmetic Interventions for Skin Microbiome Modulation: Current Strategies and Future Directions.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Review
- Skin microbiome and cutaneous aging mechanisms and clinical implications.Frontiers in microbiology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The aging process profoundly influences not only the health and visual appearance of the skin, but also the composition of the microbial communities residing on its surface. Methods: To investigate these microbial changes, we employed a comprehensive, multi-scale approach that probes community composition, species interactions, and predicted metabolic function of the skin microbiome of the face and forearm in young and old age individuals from the United Kingdom using 16S rRNA gene sequencing. Results: Our findings revealed significant and site-specific age-related shifts in the microbiome involving diversity, interpersonal heterogeneity, network connectivity, and metabolic potential, suggesting loss of microbiome robustness and a shift towards a hyperdiversified, fragile microbial community in old age. Furthermore, we applied Dirichlet Multinomial Mixtures to uncover novel age-driven microbiome profiles unique across each skin site, highlighting Discussion: Overall, through examining the aging skin microbiome from a systems perspective, our study reinforces and enhances the findings from previous aging microbiome studies and underscores the importance of site-specific differences in skin microbiome dynamics with age. These insights suggest that microbial interventions could mitigate age-related changes, enhancing skin health and wellbeing throughout life.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.