SynthesisFrontiers in medicine2025
The predictive value of neutrophil to lymphocyte ratio for abortion: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Soluble P2X7 receptor (sP2X7R) as a marker of inflammation in pregnancy.Purinergic signalling · 2026Article
- Monocyte-to-Albumin Ratio (MAR) Is Associated With All-Cause Mortality in Adult Stroke Patients: Evidence From NHANES (1999-2018).Stroke research and treatment · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Abortion usually refers to the loss of pregnancy before viability. Despite a potential link between neutrophil-lymphocyte ratio (NLR) levels and abortion, inconclusive findings remain. This review aimed to comprehensively appraise the predictive utility of NLR levels in abortion, offering a new approach to clarify its potential role as a biomarker. Methods: PubMed and Cochrane Library were searched for relevant cohort and case-control studies until September 2024. Odds ratio (OR) or weighted mean difference (WMD) with 95% CI of abortion were computed. Subgroup analyses were implemented to clarify potential sources of heterogeneity. Results: Higher NLR levels were linked to an enhanced risk of abortion as a continuous (WMD, 0.58; 95% CI: 0.29, 0.88) and dichotomous variable (OR, 1.33; 95% CI: 1.03, 1.72). In subgroup analyses, pooled results from studies with NLR cut-off>3, Asia populations, missed abortion, spontaneous abortion, and mean age>30 demonstrated an increased risk of abortion. In continuous NLR for predicting abortion, retrospective study, Europe populations, threatened abortion, recurrent pregnancy loss, and abortion had an enhanced risk of abortion for higher NLR levels as a dichotomous variable. Conclusion: Pooled analyses demonstrated that higher NLR levels may predict abortion. Further investigations need to determine whether these findings can be generalized to all populations. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/485726.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.