Evidence map›Paper›PMID 41049447›Full record

ArticleInternational journal of medical sciences2025

Clinical Efficacy of Topical Ziyun Ointment in Improving Skin Hydration and Reducing Transepidermal Water Loss in Psoriasis.

Yu-Ping Hsiao, Wen-Li Ou, Chun-Te Lu, Jiunn-Liang Ko, Chih-Ting Hsu, Sheau-Chung Tang

Abstract read
In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Ping HsiaoInstitute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Wen-Li OuSchool of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Chun-Te LuInstitute of Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan.
Jiunn-Liang KoInstitute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Chih-Ting HsuInstitute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan.
Sheau-Chung TangDepartment of Nursing, National Taichung University of Science and Technology, Taichung 406, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ziyun Ointment, a traditional Chinese herbal remedy, is often applied externally; however, its physiological effects on the skin have not been thoroughly studied. This study aimed to assess the skin parameters of psoriasis patients before and after 12 weeks of Ziyun Ointment application.

methods30 participants were recruited and classified into mild, moderate, and severe. The pre-test and post-test measurements of skin parameters, including melanin and erythema index, stratum corneum lipids, stratum corneum hydration, and transepidermal water loss (TEWL), were conducted using the non-invasive Cutometer Dual MPA580.

result80% of the patients improved PASI, and the PASI score was significantly reduced by 2.58 ± 1.35 (

conclusionZiyun Ointment retains the hydration in the skin and reduces the loss of moisture from the skin. We also suggest that Ziyun Ointment be used for at least 12 weeks to observe significant improvements. Ziyun Ointment has a physiological significance in maintaining skin moisture.

Indexed as

Drugs, Chinese HerbalPsoriasisSkinWater Loss, InsensibleAdultFemaleHumansMaleMiddle AgedOintmentsSeverity of Illness IndexTreatment OutcomeDrugs, Chinese HerbalOintmentserythemaPASI scorespsoriasisTransepidermal Water Loss.Ziyun Oointment

Identifiers

PMID41049447
PMCPMC12492351

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.