ArticleFrontiers in aging neuroscience2025
Association between cardiovascular disease risk, regional brain age gap, and cognition in healthy adults.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Depression and Anxiety in Pulmonary Hypertension Associated With Congenital Heart Disease: Pathophysiology and Clinical Implications of the Heart-Brain Axis.Journal of the Saudi Heart Association · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiovascular disease (CVD) and its associated risk factors accelerate neurodegeneration and cognitive decline. This study examined relationships between CVD risk, cognition, and Brain Age Gap (BAG)-the difference between MRI-predicted brain age and chronological age. While prior research has linked CVD risk factors to global (i.e., "whole-brain") BAG, we extend these findings by examining region-specific associations, offering more spatially precise insights into brain aging across the cortex. Methods: Cross-sectional data from 187 participants in the University of South Carolina's Aging Brain Cohort (ABC) were analyzed. T1-weighted MRI scans were processed with Results: 10-year CVD risk and HAG were significantly correlated with global BAG ( Conclusion: CVD risk is associated with global and regional brain aging, with specific cortical regions demonstrating greater vulnerability to CVD risk burden than others. These findings highlight the added value of regional BAG analyses, which reveal heterogeneity in aging patterns not captured by global estimates alone and may clarify vascular contributions to brain aging.
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