ArticleResearch (Washington, D.C.)2025
Noninvasive Computed Tomography-Based Quantification of Tumor Fibrosis Predicts Pancreatic Cancer Response to Gemcitabine/Nab-Paclitaxel.
Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ultrasound radiomics-based machine learning models for differentiating diabetic kidney disease from non-diabetic kidney disease in type 2 diabetes.BMC nephrology · 2026Article
- Dual-energy CT extracellular volume fraction for predicting the chemotherapeutic response in pancreatic ductal adenocarcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Article
- Baseline dual-layer spectral CT-based habitat analysis for preoperative prediction of recurrence in pancreatic cancer after radical resection and its association with tumor-stroma ratio.Abdominal radiology (New York) · 2026Article
- Early prediction of response to chemotherapy with Cetuximab in colorectal liver metastasis with contrast-enhanced ultrasound perfusion analysis.BMC gastroenterology · 2026Article
- Integrated CT Foundation Model and Radiomic Features Define Clinically and Biologically Distinct Colorectal Cancer Subtypes.Research (Washington, D.C.) · 2026Article
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Authors and funding
20 authors.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis. Chemotherapy remains the mainstay for unresectable cases, yet regimens like AG (gemcitabine/nab-paclitaxel) exhibit heterogeneous efficacy. Tumor fibrosis has emerged as a potential predictor of treatment response but lacks validated noninvasive assessment methods. To address this, in this multicenter study, tumor fibrosis was quantified in 361 patients with resectable PDAC from SYSUCC, XYCSU, and TCGA cohorts using deep learning-based tissue segmentation on hematoxylin and eosin-stained whole-slide images. Fibrosis was defined as stromal proportion, and its association with overall survival (OS) was evaluated. Transcriptomic profiling was performed in 51 XYCSU cases to validate the biological relevance of fibrosis quantification. A radiomics model (RM) was then developed using preoperative contrast-enhanced computed tomography (CT) scans from SYSUCC to predict fibrosis and externally validated in XYCSU. Clinical utility was assessed in an independent cohort of 295 unresectable PDAC patients treated with AG, FOLFIRINOX, or SOXIRI. High fibrosis correlated with prolonged OS across resectable cohorts (all
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.