Evidence map›Paper›PMID 41049949›Full record

ArticleCureus2025

Nutrition-Based, High-Protein Adjunct Therapy for Hashimoto's Thyroiditis: A Case Report.

Savannah L Limbaugh, Lisa A Ennessy, Karen S Davis, Vicki T Allen

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Savannah L LimbaughClinical Nutrition, Maryland University of Integrative Health, Laurel, USA.
Lisa A EnnessyClinical Nutrition, Maryland University of Integrative Health, Laurel, USA.
Karen S DavisClinical Nutrition, Maryland University of Integrative Health, Laurel, USA.
Vicki T AllenClinical Nutrition, Maryland University of Integrative Health, Laurel, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hashimoto's thyroiditis (HT) can cause symptoms as weight gain and fatigue, or with more drastic ones like lowered blood pressure, low resting heart rate, or manifestation of nutritional deficiencies. While diagnostic criteria for HT are aimed at detecting abnormalities in thyroid hormones, there is scarce data on nutritional markers for concerns related to the manifestation of thyroid disease symptoms. We report the case of a 21-year-old overweight female with a 10-year history of HT. The patient developed severe bilateral lower extremity muscle weakness and fatigue, severe enough to restrict exercise activity and normal daily activity, and affect the quality of life. These symptoms were accompanied by relatively normal blood markers for thyroid hormones. Adjunct therapy consisted of a high-protein diet, utilizing the one-gram per pound of body weight method, supplemented with daily essential amino acids, including tyrosine, valine, and leucine. With nutritional intervention implementation, the patient's symptoms of weight loss, fatigue, and lack of endurance capacity resolved over two weeks. She was able to restart daily exercise without symptom relapse. The report highlights the resolution of symptoms in an HT patient and delves into the connection between amino acid deficiency and thyroid disease, along with the novel nutritional intervention employed for managing this patient's case.

Indexed as

amino acid supplementationcase reportfatiguehashimoto’s thyroiditishigh-protein diethypothyroidismleg weakness

Identifiers

PMID41049949
PMCPMC12495900

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.