ArticleFrontiers in immunology2025
Multi-omics profiling identifies berberine and salidroside as potential immunoregulatory compounds in radiation-induced skin injury.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Radiation-induced skin injury is a significant concern in nuclear accidents and cancer radiotherapy (RT). Skin damage ranges from mild erythema to severe ulceration, which significantly affects the patients' quality of life. While previous studies have highlighted the role of the apoptotic pathway, its precise mechanism in radiation-induced skin damage remains unclear. Method: First, single-cell RNA and RNA-seq datasets were searched using the Gene Expression Omnibus (GEO) database, and further subgroup analysis of fibroblast skin cells, pseudotime analysis, and cell-cell communication analysis were conducted to determine the important state during fibroblast differentiation. Next, we analyzed and screened the key genes in the RNA-seq data. Finally, we performed SA-β-gal staining, flow cytometry, and qRT-PCR in an Result: The apoptotic pathway plays a crucial role in fibroblasts. Subsequent analysis of fibroblast subtypes revealed different subtypes, including MMP3, Coch, Apod, and Eif4e. Enrichment analysis further demonstrated a significant upregulation of apoptosis in MMP3 fibroblasts (FIB). Pseudotime analysis indicated that MMP3 FIB exhibited high stemness within the fibroblast differentiation trajectory, while intercellular communication analysis underscored the critical role of TGF-β in fibroblast subtype interactions. Additionally, RNA-Seq analysis identified TGFBR2 as a key gene. Conclusion: This study integrates single-cell and bulk transcriptomic analyses to reveal apoptosis-sensitive fibroblast subtypes involved in radiation-induced skin injury. MMP3
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