Evidence map›Paper›PMID 41051685›Full record

ReviewJournal of cardiovascular translational research2025

Association of Copper with Atherosclerosis and Treatment Strategies.

Jiawei Li, Lin Yi, Lingna Zhang, Lufan Shen, Yuyuan Lu, Hong Wang, Xiaojie Chen, Yushun Kou, Yiyuan Wang, Ruiling Ma and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiawei Li *School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Lin Yi *School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China. yilin@gszy.edu.cn.ORCID 0009-0008-2448-6902
Lingna ZhangSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Lufan ShenSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Yuyuan LuSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Hong WangSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Xiaojie ChenSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Yushun KouSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Yiyuan WangSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Ruiling MaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China.
Zhenjie TengDepartment of Cardiovascular Medicine, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu Province, China. 761383712@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the formation of fibrous fatty lesions or plaques within the arterial wall, which causes a large amount of morbidity and mortality worldwide. Copper is a mineral nutrient essential for the human body and is essential for maintaining the normal function of multiple human systems, including the cardiovascular system. Imbalance of copper homeostasis has been increasingly considered as a key factor affecting the pathogenesis and disease progression of AS. This article summarizes the complex association between copper ions and AS, focusing in particular on the key roles of copper metabolism, copper homeostasis and copper death. It aims to reveal the mechanism of action of copper ions in AS and explore treatment strategies targeting copper metabolism, copper death and copper homeostasis imbalance in relation to atherosclerosis, with a view to providing new perspectives and strategies for the treatment and prevention of AS.

Indexed as

ArteriesAtherosclerosisChelating AgentsCopperAnimalsHomeostasisHumansPlaque, AtheroscleroticSignal TransductionChelating AgentsCopperAtherosclerosisCopperCopper homeostasisCopper metabolismCuproptosis

Identifiers

PMID41051685

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.