Evidence mapPaperPMID 41052791Full record

ReviewJournal of labelled compounds & radiopharmaceuticals2025

Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers.

Michael L Schulte, Adam J Rosenberg

Abstract readReview
In one paragraph

Review in Journal of labelled compounds & radiopharmaceuticals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael L SchulteMedical Imaging Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Adam J RosenbergVanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-2459-7043

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · VANDERBILT UNIVERSITY MEDICAL CENTER · 1995 to 2025
$32.7M
Direct Methylation with [11C]CO2 for Production of RadiopharmaceuticalsR21EB037241 · VANDERBILT UNIVERSITY MEDICAL CENTER · 2025 to 2025
$700k
NIBIB NIH HHS R21 EB037241NIH HHS P30CA068485
6 · The paper itself

Abstract

As the field of radiochemistry moves toward the rapid development and translation of radiopharmaceuticals, the radiosynthetic methodology and manufacturing are becoming more and more refined. As the use of radiopharmaceuticals in clinical research is one of the primary goals of radiochemistry research, compliance with cGMP regulations is a key factor in radiosynthesis developments. This review is primarily focused on the automation of the radiosynthesis on modules, with a special focus on the use of disposable cassettes for the reactors and flow-paths. This review aims to cover the developments and current state-of-the-art for cassette-based radiosynthesis of carbon-11 radiopharmaceuticals.

Indexed as

Carbon RadioisotopesRadiochemistryRadiopharmaceuticalsAutomationChemistry Techniques, SyntheticCarbon-11Carbon RadioisotopesRadiopharmaceuticalsautomationcarbon‐11cGMPradiochemistry

Identifiers

PMID41052791
PMCPMC12500388

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.