ArticleTranslational psychiatry2025
Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Precision Drug Delivery Strategies for Treatment-Resistant Depression: Opportunities and Challenges of FUS-BBBO and Spatial Molecular Profiling.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The rostral anterior cingulate cortex (rACC) has been identified as a key region in treatment-resistant depression (TRD), potentially influencing the adaptive interplay between the default mode network and other critical neural networks. This study aims to further uncover the role of the rACC in TRD by investigating its differential connectivity during tasks that evoke conscious and non-conscious emotional responses. Thirty-one TRD patients, 35 treatment-sensitive depression (TSD) patients, and 37 healthy controls (HC) underwent 3T fMRI while performing tasks designed to elicit emotional responses to facial expressions under supraliminal and subliminal conditions. Connectivity patterns of the rACC were analyzed using seed-based and region-of-interest (ROI) approaches. During the processing of positive emotions in the subliminal task, TRD patients showed increased rACC connectivity to the cerebellum and middle temporal gyrus, compared to HC and TSD. Furthermore, significant hypoconnectivity between the rACC and hippocampus was found in the TRD, during the supraliminal processing of positive emotions, compared to TSD and HC. Altered neural connectivity to both subliminal and supraliminal processing of positive facial emotion distinguishes TRD from healthy individuals and patients who respond to depression treatments. This observation fits with anhedonia symptoms that persist in TRD and our findings point to altered connectivity between the rACC and regions involved in emotion regulation and contextualisation during non-conscious processing of positive stimuli.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.