ReviewCell death discovery2025
From mechanisms to markers: role of pyroptosis in revolutionizing thyroid cancer care.
Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Triptolide in Combination with the Gli1 Inhibitor GANT61 Eradicates Anaplastic Thyroid Cancer by Suppressing Cancer Stem Cell Self-Renewal and Enhancing Apoptosis and Pyroptosis.International journal of biological sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global incidence of thyroid cancer, especially papillary thyroid cancer, has increased in recent decades, making it a significant global health issue. Pyroptosis, an important form of programmed cell death, is characterized by pore formation in the cell membrane, membrane rupture, cell swelling, and the subsequent release of cellular contents. Factors released during this process, such as interleukin-1β and interleukin-18, amplify inflammatory effects and trigger immune activation. Increasing evidence indicates that pyroptosis has either tumour-promoting or tumour-suppressing effects at various stages of tumour progression, which has garnered significant attention and warrants further investigation. Thus, harnessing the tumour-inhibitory effects while mitigating the tumour-promoting effects of pyroptosis represents a promising therapeutic strategy for the clinical management of thyroid cancer. Furthermore, pyroptosis-related genes are significantly correlated with the prognosis of thyroid cancer. Therefore, this review provides an overview of the current research regarding the role of pyroptosis in thyroid cancer, focusing on its mechanisms, therapeutic targets, and predictive biomarkers. These findings highlight the importance of pyroptosis in thyroid cancer and offer valuable insights for the development of innovative treatment strategies and accurate prognostic markers.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.