Evidence map›Paper›PMID 41053133›Full record

ArticleNature communications2025

Impact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors.

Anne Jouinot, Yoann Martin, Florian Violon, Thomas Foulonneau, Yanis Bendjelal, Philip Calvet, Brigitte Izac, Franck Letourneur, Céline Bertholle, Muriel Andrieu and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Anne JouinotUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France. anne.jouinot@inserm.fr.ORCID http://orcid.org/0000-0002-7922-2065
Yoann MartinUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Florian ViolonUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Thomas FoulonneauUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Yanis BendjelalUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Philip CalvetUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0009-0007-3509-9708
Brigitte IzacUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Franck LetourneurUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0001-9465-4774
Céline BertholleUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Muriel AndrieuUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0003-0170-2250
Rachel OnifarasoaniainaUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Maryline FavierUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0002-2818-3369
Charlène de GuitautENS Paris-Saclay, Gif-sur-Yvette, France.
Archibald FraikinENS Paris-Saclay, Gif-sur-Yvette, France.
Daniel de MuratUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Roberta ArmignaccoUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Nesrine BenanteurUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Maria Francesca BirtoloUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0001-8100-8394
Mathilde SibonyUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0002-1282-8732
Karine PerlemoineUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Patricia VaduvaUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0003-3195-1629
Lucas BouysUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0003-1743-1598
Fidéline Bonnet-SerranoUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0002-6628-8807
Bertrand DoussetUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Martin GaillardUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Eric PasmantUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Maxime BaratUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Anthony DohanUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Magalie HaissaguerreDepartment of Endocrinology, diabetes and nutrition, University of Bordeaux, CHU Haut Leveque, Pessac, France.
Antoine TabarinDepartment of Endocrinology, diabetes and nutrition, University of Bordeaux, CHU Haut Leveque, Pessac, France.
Rossella LibéUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Laurence GuignatDepartment of Endocrinology and National Reference Center for Rare Adrenal Disorders, AP-HP, Hôpital Cochin, Paris, France.
Lionel GroussinUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Annabel BerthonUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.
Bruno RagazzonUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0001-9476-4973
Jérôme BertheratUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID http://orcid.org/0000-0003-2551-3008
Guillaume AssiéUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France. guillaume.assie@aphp.fr.

Funding

Agence Nationale de la Recherche (French National Research Agency) 18-CE14-0008-01
6 · The paper itself

Abstract

Adrenocortical carcinomas (ACC) are aggressive and resistant to medical treatment. This study reports a single-nucleus transcriptome atlas of steroid and microenvironment cells in 38 human normal adrenals and adrenocortical tumors. We identify intermediate-state cells between glomerulosa and fasciculata, a transition state in the centripetal trans-differentiation of normal steroid cells. In tumors, steroid cells show expression programs reflecting this zonation. Although ACC microenvironment is scarce, its signatures combine with those of steroid cells into ecotypes. A first ecotype combines cancer-associated fibroblasts, tumor-associated endothelial cells, with hypoxia and mitosis signatures in steroid cells. Another ecotype combines exhausted T cells, with fasciculata steroid signature. These ecotypes are associated with poor survival. Conversely, a third ecotype combines inflammatory macrophages, with reticularis steroid signature, and better outcome. These steroid/microenvironment cells interplays improve outcome predictions and may open therapeutic options in aggressive ACC, through immune microenvironment activation by modulating glucocorticoids/androgens balance.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaCell NucleusSteroidsTumor MicroenvironmentAdrenal GlandsCancer-Associated FibroblastsCell DifferentiationFemaleGene Expression Regulation, NeoplasticHumansMaleSingle-Cell AnalysisTranscriptomeSteroids

Identifiers

PMID41053133
PMCPMC12501071

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.