Evidence map›Paper›PMID 41053148›Full record

ArticleScientific reports2025

Thrombin induces degradation of murine intervertebral discs via angiogenesis and M1-like polarization of macrophages.

Rikito Tatsuno, Takashi Ando, Taro Fujimaki, Yoshihiro Takayama, Tetsuro Ohba, Hirotaka Haro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rikito TatsunoDepartment of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Takashi AndoDepartment of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. tando@mtg.biglobe.ne.jp.
Taro FujimakiDepartment of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Yoshihiro TakayamaDepartment of Orthopedic Surgery, Yamanashi Kosei Hospital, Yamanashi, Japan.
Tetsuro OhbaDepartment of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Hirotaka HaroDepartment of Orthopedic Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Funding

Japan Society for the Promotion of Science 19K09594Japan Society for the Promotion of Science 23K08584
6 · The paper itself

Abstract

With the marked aging of the global population, the prevalence of musculoskeletal disorders due to low back pain has escalated, with an associated increase in the number of individuals requiring nursing care. To help identify novel therapies for treating disc degeneration, we examined the roles of thrombin and macrophages in intervertebral disc degeneration, a significant cause of low back pain. Experiments using a needle-puncture mouse tail model of disc degeneration confirmed that this process led to the production of thrombin and MCP-1. Thrombin altered macrophage markers, increasing the population of M1 markers and decreasing that of M2 markers. Therefore, increased thrombin and MCP-1 production may induce disc degeneration by inducing M1-type polarization of migrated macrophages. Disc tissue M1-macrophage levels were elevated 3 weeks after puncture. Administering SCH79797, a thrombin receptor (PAR1) antagonist, suppressed thrombin-induced disc degeneration and inhibited macrophage migration, M1 polarization, VEGF production, and angiogenesis. These findings suggest that the suppression of thrombin function in intervertebral disc inflammation is a novel and promising approach for treating disc degeneration.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationMacrophagesNeovascularization, PathologicThrombinAngiogenesisAnimalsCell MovementCell PolarityChemokine CCL2Disease Models, AnimalMaleMiceMice, Inbred C57BLVascular Endothelial Growth Factor AChemokine CCL2ThrombinVascular Endothelial Growth Factor AAngiogenesisDisc degenerationLow back painMacrophage polarizationThrombin

Identifiers

PMID41053148
PMCPMC12501369

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.