Evidence map›Paper›PMID 41053987›Full record

ArticleRedox report : communications in free radical research2025

Expression, localization and regulation of NADPH oxidases in pancreatic beta cells.

Davidson Correa de Almeida, Eloisa Aparecida Vilas-Boas, Paulo Henrique Coelho Ferreira, Sandra Mara Ferreira, Angelo Rafael Carpinelli, Fernanda Ortis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Davidson Correa de AlmeidaLaboratory of Study of β Cell Death Molecular Mechanisms, Department of Cell and Development Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-4285-0081
Eloisa Aparecida Vilas-BoasLaboratory of Endocrine Pathophysiology and Redox Processes, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-1565-1618
Paulo Henrique Coelho FerreiraLaboratory of Study of β Cell Death Molecular Mechanisms, Department of Cell and Development Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0009-0006-6411-4439
Sandra Mara FerreiraLaboratory of the Endocrine Pancreas and Metabolism, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, Brazil.ORCID 0000-0003-2642-2802
Angelo Rafael CarpinelliLaboratory of Physiology of Insulin Secretion, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-0781-4934
Fernanda OrtisLaboratory of Study of β Cell Death Molecular Mechanisms, Department of Cell and Development Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesReactive oxygen species (ROS) are short-lived and act in a site-specific manner, underscoring the importance of identifying the subcellular localization of their sources. ROS-generating NADPH oxidases (NOX) regulate pancreatic beta cell (dys)function. However, their subcellular localization and cytokine-mediated regulation in these cells remain largely unknown. We characterized the expression, subcellular localization and time-dependent cytokine-induced regulation of NOX isoforms in beta cells.

methodsIsoforms were studied via RT-qPCR, immunoblotting and immunofluorescence in rat islets and beta cell lines.

resultsBeta cells express DUOX1 and DUOX2 proteins and

conclusionThe absence of

Indexed as

Insulin-Secreting CellsNADPH OxidasesAnimalsCell LineDual OxidasesEndoplasmic ReticulumRatsReactive Oxygen SpeciesDual OxidasesNADPH OxidasesReactive Oxygen Speciesdiabetesinsulin secretioninsulitisNADPH oxidasespancreatic beta cells

Identifiers

PMID41053987
PMCPMC12507117

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.