Evidence map›Paper›PMID 41055836›Full record

ArticleChembiochem : a European journal of chemical biology2025

Mitochondria-Targeted Delivery of siRNA by Amphiphilic Nanovectors Self-Assembled from a Cationic [4]Helicene-Squalene Ester.

Lamiaa M A Ali, Dan-Dan Su, Rebecca Mucci, Kévin Martin, Mihail Barboiu, Jérôme Lacour, Nadir Bettache, Sébastien Ulrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lamiaa M A AliInstitut des Biomolécules Max Mousseron (IBMM), CNRS, ENSCM, Université of Montpellier, Montpellier, France.
Dan-Dan SuInstitut des Biomolécules Max Mousseron (IBMM), CNRS, ENSCM, Université of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0001-9220-5473
Rebecca MucciDepartment of Organic Chemistry, University of Geneva, Quai Ernest-Ansermet 30, Genève 4, 1211, Switzerland.ORCID https://orcid.org/0000-0001-6453-0404
Kévin MartinDepartment of Organic Chemistry, University of Geneva, Quai Ernest-Ansermet 30, Genève 4, 1211, Switzerland.
Mihail BarboiuInstitut Européen des Membranes, Adaptive Supramolecular Nanosystems Group, ENSCM, CNRS, University of Montpellier, Place Eugène Bataillon CC 047, Montpellier, F-34095, France.ORCID https://orcid.org/0000-0003-0042-9483
Jérôme LacourDepartment of Organic Chemistry, University of Geneva, Quai Ernest-Ansermet 30, Genève 4, 1211, Switzerland.ORCID https://orcid.org/0000-0001-6247-8059
Nadir BettacheInstitut des Biomolécules Max Mousseron (IBMM), CNRS, ENSCM, Université of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0001-5426-7024
Sébastien UlrichInstitut des Biomolécules Max Mousseron (IBMM), CNRS, ENSCM, Université of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0002-6080-3345

Funding

Association pour la Recherche sur le Cancer ARCPJA2021060003831Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 200020_207539Université de Genève 200020_184843
6 · The paper itself

Abstract

The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge. Herein, a small conjugate molecule, combining a cationic [4]helicene moiety with a lipophilic squalene tail, yields amphiphilic nanoassemblies capable of effectively complexing siRNA within the mitochondria. A proof-of-concept in HCT 116 colorectal cancer cells was evidenced by Western blot for the delivery of siRNA silencing the protein expression of the mitochondria-encoded cytochrome c oxidase subunit 1 gene.

Indexed as

MitochondriaNanoparticlesRNA, Small InterferingSqualeneCationsElectron Transport Complex IVEstersHCT116 CellsHumansCationsElectron Transport Complex IVEstersRNA, Small InterferingSqualeneamphiphileshelicenemitochondria targetingnano‐assemblyRNA delivery

Identifiers

PMID41055836
PMCPMC12596926

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.