ArticleNature communications2025
Soft bioelectronics embedded with self-confined tetrahedral DNA circuit for high-fidelity chronic wound monitoring.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation.Biosensors · 2026Review
- Wearable Electronics for Precision Diagnosis Through Advanced Manufacturing and Integration.Nano-micro letters · 2026Review
- pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Engineering Organ Conformality for Precise Intracellular Delivery.Research (Washington, D.C.) · 2026Article
- Electric-based dressing for wound management.Frontiers in cellular and infection microbiology · 2026Review
- Wearable Electrochemical Biosensors for Monitoring and Management of Chronic Wounds.Biosensors · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Monitoring wound protein biomarkers, especially inflammation-related proteins, is essential to assess wound progression and guide treatment. However, high-fidelity wound biosensing is challenging because of current biosensors' limitations in detecting low-abundance proteins and their vulnerabilities to mechanical deformation, biofouling, and performance degradation. Here, we introduce a soft bioelectronics embedded with Self-Confined Tetrahedral DNA circuit (SCTD) for wound monitoring. In SCTD, proteins in wound exudate trigger DNA self-circulation amplification confined in the hydrophilic area, decreasing detection limits by an order of magnitude. The tetrahedral DNA structure ensures excellent mechanical stability (within 3% variation after 1000 bending cycles), prolonged stability (within 8% signal attenuation over 4 weeks), and reduced biofouling (over 50% BSA adhesion reduction). Coupled with wireless readout, this platform simultaneously monitors multiple wound healing-related proteins (TNF-α, IL-6, TGF-β1, and VEGF) and biophysical parameters. The wireless platform demonstrates accurate in-situ monitoring of both non-infected and infected wounds on diabetic male mice without hindering the healing process, offering quantitative and comprehensive evaluation to guide treatment.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.