ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Effects of levodopa on motor and cerebellar network connectivity in Parkinson's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Multimodal brain network topology and enhanced computer-aided diagnosis in Parkinson's Disease: a systematic review and meta-analysis.NPJ digital medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundLevodopa is the most effective treatment for motor symptoms in Parkinson's disease (PD), but its therapeutic mechanisms and effects on resting-state functional connectivity (FC) remain incompletely understood. This study aims to investigate the acute impact of levodopa on FC within motor-related networks in PD.
methodsTwenty-seven patients with PD underwent resting-state functional magnetic resonance imaging on 2 consecutive days under OFF and ON dopaminergic therapy conditions. Ten age-matched healthy controls were included for comparison. FC analyses targeted 57 regions of interest (ROIs) across the basal ganglia, motor cortex, and cerebellum, assessed using ROI-to-ROI connectivity and graph theory.
resultsLevodopa altered FC in motor circuits, with six connections increasing and seven decreasing. Key changes involved enhanced FC between the right globus pallidus externa and left pre-supplementary motor area, and reduced FC between the right cerebellum 10 and bilateral primary motor cortex. These changes were correlated with improvements in UPDRS-III scores. Graph metrics revealed increased clustering in the right cerebellar Crus I and reduced global efficiency in the left primary motor cortex.
conclusionsLevodopa modulates FC in motor-related networks in PD, enhancing cerebellar and PPN connectivity while reducing cortical coupling. These changes, reflected in graph-theoretical metrics, suggest a shift from global integration toward a more modular and locally segregated organization. This reconfiguration may underlie levodopa's therapeutic effects on motor symptoms.
Indexed as
Identifiers
41057552What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.