Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial.
Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02817074 (MIND Diet Intervention to Prevent Alzheimer's Disease), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MIND Diet Intervention to Prevent Alzheimer's Disease
Who cites it
6 citing papers in PubMed.
- Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Review
- Review
- MIND diet moderates the associations between cerebrovascular and neurodegenerative disease burden and cognition.Frontiers in nutrition · 2026Article
- Exercise-induced modulation of astrocyte in Alzheimer's disease: mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Targeting the blood-brain barrier with phytochemicals to attenuate vascular cognitive impairment: mechanisms and therapeutic potential across etiologies.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionWe examined whether participant characteristics, including sociodemographics, APOE ε4 allele, lifestyle factors, and cardiovascular risk factors, modified the effect of the Mediterranean-Dietary Approach to Systolic Hypertension Intervention for Neurodegenerative Delay (MIND).
methodsThe MIND trial (NCT02817074) randomized adults 65 to 85 years who were overweight or obese to the MIND diet or control diet conditions. A linear mixed-effects model was used to examine whether participant characteristics modified the effect of MIND on the annual change in a global cognition score derived from a battery of 12 neurocognitive tests.
resultsOn average, participants (N = 604) were 70.4 years old, 65.5% female, and with a body mass index (BMI) of 33.9 kg/m DISCUSSION: The MIND diet may have cognitive benefits in people with obesity, particularly BMI ≥ 35. CLINICAL TRIAL REGISTRATION NUMBER: NCT02817074 HIGHLIGHTS: This study examined potential effect modifiers of the MIND diet on cognition. BMI emerged as a significant effect modifier. In those with BMI ≥ 35 kg/m
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.