Evidence map›Paper›PMID 41058191›Full record

Trial reportBrain and behavior2025

Renal Function and Efficacy of Remote Ischemic Conditioning in Acute Moderate Ischemic Stroke: A Post Hoc Analysis of RICAMIS Trial.

Xiao-Yi He, Yu Cui, Jia-Qi Wang, Lu Wang, Hui-Sheng Chen

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03740971 (Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03740971 nacompletednot on this map

Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS): a Prospective, Random, Open Label, Blinded End Point, Multi-center Study

TypeinterventionalSponsorGeneral Hospital of Shenyang Military RegionRan2018 to 2021Enrolled1,800ConditionsStrokeArmsRemote Ischemic Conditioning treatment, Guideline-based therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiao-Yi HeDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Yu CuiDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.ORCID https://orcid.org/0000-0002-4925-1500
Jia-Qi WangDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Lu WangDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Hui-Sheng ChenDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.ORCID https://orcid.org/0000-0002-7486-1992

Funding

the Science and Technology Project Plan of Liaoning Province 2022JH2/101500020
6 · The paper itself

Abstract

backgroundEmerging evidence supports the therapeutic potential of remote ischemic conditioning (RIC) in acute stroke management. This post hoc analysis aims to elucidate the relationship between renal function and the efficacy of RIC.

methodsThis post hoc analysis utilized the complete case dataset from the RICAMIS trial, enrolling acute ischemic stroke patients with documented renal function within 48 h of symptom onset. Participants were categorized into three groups based on their estimated glomerular filtration rate (eGFR) at admission: normal (≥ 90 mL/min/1.73 m

resultsOf the 1652 patients evaluated, 941 had normal renal function, 605 had mildly impaired renal function, and 106 had moderate to severely impaired renal function. In comparison to the control group, RIC was associated with a higher probability of achieving the primary outcome in patients with normal renal function (69% vs. 64%) and those with mildly impaired renal function (66.7% vs. 59.7%). However, this association was not observed in patients with moderate to severely impaired renal function (64.1% vs. 66%, p = 0.428). There was no significant interaction between renal function and the efficacy of RIC (adjusted p value = 0.970).

conclusionCompared with moderate to severely impaired renal function, RIC is associated with an increased likelihood of excellent functional outcome at 90 days in patients with normal and mildly impaired renal function.

trial registrationClinicalTrials.gov identifier: NCT03740971.

Indexed as

Ischemic PreconditioningIschemic StrokeKidneyAgedAged, 80 and overFemaleGlomerular Filtration RateHumansMaleMiddle AgedTreatment Outcomeacute ischemic strokefunctional outcomeremote ischemic conditioningrenal function

Identifiers

PMID41058191
PMCPMC12504810

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.