Evidence map›Paper›PMID 41058567›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells.

Samuel D Walton, Emily C Burns-Ray, John Henry Dasinger, Sadaf Hasan, Kaitlyn E Baldwin, Mary Cherian-Shaw, Justine M Abais-Battad, David L Mattson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuel D WaltonDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0002-8460-2214
Emily C Burns-RayDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0003-4653-609X
John Henry DasingerDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0001-6667-0427
Sadaf HasanDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0002-8270-2705
Kaitlyn E BaldwinDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).
Mary Cherian-ShawDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0002-8079-6453
Justine M Abais-BattadDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0001-5252-0903
David L MattsonDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA (S.D.W., E.C.B.-R., J.H.D., S.H., K.E.B., M.C.-S., J.M.A.-B., D.L.M.).ORCID 0000-0002-5401-0269

Funding

The Impact of Obesity and Leptin on the Development of Immune System Dysfunction and Hypertension in Females with Systemic Lupus ErythematousU54HL169191 · NHLBI · AUGUSTA UNIVERSITY · PI Daria Ilatovskaya · 2023 to 2026
$7.4M
Deep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training CoreTL1DK139566 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID M POLLOCK · 2023 to 2026
$3.6M
Deep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking CoreU2CDK133422 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kelly Hyndman · 2023 to 2026
$2.8M
Gut Metabolites, T cells, and Salt-Sensitive HypertensionR01HL166458 · NHLBI · AUGUSTA UNIVERSITY · PI David L. Mattson, Aaron James Polichnowski · 2023 to 2026
$2.4M
CD14 and Salt-Sensitive HypertensionR01HL161231 · NHLBI · AUGUSTA UNIVERSITY · PI MATTSON, DAVID L. · 2022 to 2025
$2.0M
American Heart Association-American Stroke Association 25SFRNPCKMS1467444NHLBI NIH HHS R01 HL161231NHLBI NIH HHS R01 HL166458NHLBI NIH HHS U54 HL169191NIDDK NIH HHS TL1 DK139566NIDDK NIH HHS U2C DK133422
6 · The paper itself

Abstract

backgroundInfiltration of T cells into the kidney of Dahl salt-sensitive (SS) rats accompanies SS hypertension and renal damage. Genetic deletion of T cells on the SS background (SS

methodsAdoptive transfer of purified CD (cluster of differentiation) 4+ or CD8+ T cells isolated from SS rats or from rats with a genetic deletion of a subunit of NOX2 was performed into the SS

resultsNo differences were observed in rats receiving CD8+ T cells. Flow cytometric analysis documented equal reconstitution of CD3+ cells in the adoptive transfer rats. A gene expression analysis demonstrated upregulation of inflammatory genes in the CD4+ cells in the kidney of the SS rats compared with the T cells of rats lacking functional NOX2. Subsequent experiments documented a positive correlation between CD4+ T cells in diseased human kidneys and renal damage, providing a translational aspect to this study.

conclusionsIn summary, these studies indicate that CD4+ T cells amplify SS hypertension and renal damage in the Dahl SS rats via an NOX2-dependent mechanism.

Indexed as

CD4-Positive T-LymphocytesHypertensionKidneyNADPH Oxidase 2Adoptive TransferAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalMaleRatsRats, Inbred DahlCybb protein, ratNADPH Oxidase 2hypertensionkidneyNADPH oxidase 2rats, inbred dahlT-lymphocytes

Identifiers

PMID41058567
PMCPMC12673866

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.