Evidence map›Paper›PMID 41059057›Full record

ArticleFrontiers in microbiology2025

Associations between relative abundances of

Samantha A Harker, Kevin S Bonham, Shelley Hoeft McCann, Alexandra R Volpe, Qiyun Zhu, Viren D'Sa, Daphne Koinis-Mitchell, Sean C L Deoni, Vanja Klepac-Ceraj, Candace R Lewis

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samantha A HarkerSchool of Life Sciences, Arizona State University, Tempe, AZ, United States.
Kevin S BonhamDepartment of Biological Sciences, Wellesley College, Wellesley, MA, United States.
Shelley Hoeft McCannDepartment of Biological Sciences, Wellesley College, Wellesley, MA, United States.
Alexandra R VolpeDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, United States.
Qiyun ZhuSchool of Life Sciences, Arizona State University, Tempe, AZ, United States.
Viren D'SaDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, United States.
Daphne Koinis-MitchellDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, United States.
Sean C L DeoniBill & Melinda Gates Foundation, Seattle, WA, United States.
Vanja Klepac-CerajDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, United States.
Candace R LewisSchool of Life Sciences, Arizona State University, Tempe, AZ, United States.

Funding

Host DNA methylation as a mechanism of microbiome influence on internalizing behaviorR00HD099307 · NICHD · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LEWIS, CANDACE RENEE · 2022 to 2024
$703k
Host DNA methylation as a mechanism of microbiome influence on internalizing behaviorK99HD099307 · NICHD · TRANSLATIONAL GENOMICS RESEARCH INST · PI LEWIS, CANDACE RENEE · 2020 to 2021
$194k
NICHD NIH HHS K99 HD099307NICHD NIH HHS R00 HD099307
6 · The paper itself

Abstract

Introduction: Human epigenetics, specifically DNA methylation, and the gut microbiome are dynamic systems influenced by environmental factors, such as diet and earlylife exposures, with profound implications for health and disease. Metabolites produced by the gut microbiome interact with the host, shaping physiological processes. While prior research has linked Methods: Multiple linear regression and regularized canonical correlation analysis (rCCA) were used. Results: There were significant associations between Discussion: These findings suggest that microbiome-derived metabolites, such as folate, may modulate DNA methylation and stress physiology. This work provides new insights for exploring how the gut microbiome impacts mental health and stress resilience, offering potential pathways for microbiome-targeted interventions.

Indexed as

BifidobacteriaBifidobacteriumDNA methylationepigeneticsfolategut microbiomeHPA

Identifiers

PMID41059057
PMCPMC12498159

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.