Evidence map›Paper›PMID 41059385›Full record

ArticleFrontiers in molecular biosciences2025

Unleashing the immune modulatory potential of

Bruna Eugênia de Freitas, Armanda Rodrigues, Joana Palma-Marques, Juliana Inês Weber, Ana Valério-Bolas, Rodrigo Pedro Soares, Ana Claudia Torrecilhas, Micheli Ferla, Munira Muhammad Abdel Baqui, Raul Alexander Gonzales Cordova and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bruna Eugênia de FreitasGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Armanda RodriguesGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Joana Palma-MarquesGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Juliana Inês WeberGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Ana Valério-BolasGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Rodrigo Pedro SoaresBiotechnology Applied to Pathogens Group (BAP), Instituto René Rachou/FIOCRUZ, Belo Horizonte, Brazil.
Ana Claudia TorrecilhasQuímicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Instituto de Ciências Ambientais, Belo Horizonte, Brazil.
Micheli FerlaGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.
Munira Muhammad Abdel BaquiDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, Brazil.
Raul Alexander Gonzales CordovaDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, Brazil.
Graça Alexandre-PiresCIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Isabel Pereira da FonsecaCIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Hélida Monteiro de AndradeInstituto de Ciências Biológicas, ICB, Universidade Federal de Minas Gerais, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Gabriela Santos-GomesGlobal Health and Tropical Medicine, GHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Lisboa, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: American cutaneous leishmaniasis (ACL) constitutes a neglected skin disease that causes severe disability and significant social stigma for millions of people each year. This parasitic infection is caused by several species of the protozoan Methods: Nanoparticle tracking analysis, microscopy, proteomic methodologies, colorimetric assays, serological immune methods, PCR, and multiparametric flow cytometry were employed. Results: EVs derived from Discussion: Thus, this study's findings suggest that although

Indexed as

American cutaneous leishmaniasisextracellular vesiclesimmune modulationleishmaniaamazonensisneglected skin diseaseskin homeostasis

Identifiers

PMID41059385
PMCPMC12497982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.