Evidence map›Paper›PMID 41060489›Full record

ReviewMetabolic brain disease2025

Mushrooms for the brain: A review of the neuroprotective effects of mushroom bioactive compounds.

Tamilselvan Amutha Gokul, Kamatchi Ramesh Kumar, Mani Rama Prabha, Veeramani Veeramanikandan, Bhathini Vaikuntavasan Pradeep, Fahad Al-Asmari, Fakhria A Al-Joufi, Mohamed Hussien, Tariq Aziz, Paulraj Balaji

Abstract readReview
PubMed Publisher
In one paragraph

Review in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamilselvan Amutha GokulPG and Research Centre in Zoology, Vivekananda College (Autonomous), Tiruvedakam West (Affiliated to Madurai Kamaraj University), Madurai, TN, India.ORCID 0000-0001-9049-9359
Kamatchi Ramesh KumarPG and Research Centre in Zoology, Vivekananda College (Autonomous), Tiruvedakam West (Affiliated to Madurai Kamaraj University), Madurai, TN, India. rameshkumar@vivekanandacollege.ac.in.ORCID 0000-0003-3916-3598
Mani Rama PrabhaDepartment of Botany, Thiagarajar College (Autonomous), (Affiliated to Madurai Kamaraj University), Madurai, TN, India.ORCID 0009-0007-9846-6149
Veeramani VeeramanikandanDepartment of Microbiology, Karpagam Academy of Higher Education, Coimbatore, TN, India.ORCID 0000-0002-6235-1223
Bhathini Vaikuntavasan PradeepDepartment of Microbiology, Karpagam Academy of Higher Education, Coimbatore, TN, India.ORCID 0000-0003-3794-0103
Fahad Al-AsmariDepartment of Food and Nutrition Sciences, College of Agricultural and Food Sciences, King Faisal University, Al Ahsa, Saudi Arabia.ORCID 0000-0003-4253-2796
Fakhria A Al-JoufiDepartment of Pharmacology, College of Pharmacy, Jouf University, Aljouf, 72341, Saudi Arabia.ORCID 0000-0002-7223-9788
Mohamed HussienDepartment of Chemistry, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.ORCID 0000-0002-3551-9078
Tariq AzizDepartment of Biomedical Engineering, Shenzhen University Shenzhen, Guangdong, China. tariqckd@szu.edu.cn.ORCID 0000-0003-0905-8076
Paulraj BalajiPG and Research Centre in Biotechnology, MGR College, Hosur, Tamilnadu, India. balajipaulraj@diqcindia.com.ORCID 0000-0002-6839-4785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative and neuropsychiatric diseases pose significant challenges to individuals' well-being and healthcare systems. These conditions share common mechanisms like oxidative stress, protein aggregation, inflammation, impaired neurotransmission, mitochondrial dysfunction, and excitotoxicity. Current treatments offer limited efficacy and often come with adverse effects. Mushrooms, recognized as a valuable cultural and nutritional resource, hold therapeutic potential. As a future superfood, they contribute to overall health and well-being. Various mushroom groups have been studied for their bioactive compounds, including polysaccharides, protein complexes, peptides, terpenoids, and phenolic compounds, demonstrating efficacy in different neurodegenerative conditions. Notably, edible mushrooms have shown promise in mitigating beta-amyloid-induced neurotoxicity. This review explores the utilization of mushroom biomolecules in treating neurodegenerative diseases, offering novel research insights with preclinical and clinical trials in both rat model and humans paving the way for the development and utilization of mushroom bioactive compounds as neuroprotective agents.

Indexed as

AgaricalesBrainNeurodegenerative DiseasesNeuroprotective AgentsAnimalsHumansNeuroprotective AgentsBioactive compoundsExcitotoxicityMushroomsNeurodegenerative diseasesOxidative stress

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.