Evidence map›Paper›PMID 41060643›Full record

ArticleJAMA psychiatry2026

Cannabis Use Among Individuals With Psychosis After State-Level Commercial Cannabis Legalization.

Andrew S Hyatt, Michael William Flores, Julie Johnson, Danta Bien-Aime, A Eden Evins, Dost Öngür, Benjamin Lê Cook

Abstract read
In one paragraph

Article in JAMA psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew S HyattHealth Evaluation Research Lab, Cambridge Health Alliance, Cambridge, Massachusetts.
Michael William FloresHealth Evaluation Research Lab, Cambridge Health Alliance, Cambridge, Massachusetts.
Julie JohnsonMassachusetts Cannabis Control Commission, Worcester, Massachusetts.
Danta Bien-AimeHealth Evaluation Research Lab, Cambridge Health Alliance, Cambridge, Massachusetts.
A Eden EvinsDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Dost ÖngürDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Benjamin Lê CookHealth Evaluation Research Lab, Cambridge Health Alliance, Cambridge, Massachusetts.

Funding

Understanding the Role of Trauma Over the Lifecourse in Order to Improve Trauma-informed TreatmentP50MH126283 · NIMH · CAMBRIDGE HEALTH ALLIANCE · PI WEISS, MARGARET · 2021 to 2024
$6.6M
Impact of the New York State Medicaid Value-Based Payment Policy on Opioid Use Disorder TreatmentR01DA060795 · NIDA · CAMBRIDGE HEALTH ALLIANCE · PI Michael Flores · 2024 to 2026
$1.3M
Impact of cannabis legalization and commercialization on substance use and mental health outcomes in psychosisK23DA062173 · NIDA · CAMBRIDGE HEALTH ALLIANCE · PI Andrew Hyatt · 2025 to 2026
$354k
NIDA NIH HHS K23 DA062173NIDA NIH HHS R01 DA060795NIMH NIH HHS P50 MH126283
6 · The paper itself

Abstract

Importance: Many individuals can use cannabis without harm, but individuals with psychosis are particularly vulnerable to negative effects from cannabis. No studies to date have investigated how recreational cannabis legalization (RCL) affects cannabis use in individuals with psychosis. Objective: To assess impacts of RCL in cannabis use among individuals who have ever been diagnosed with a psychotic illness or episode in the US. Design, Setting, and Participants: This study used data from 2014 to 2022 on state-level RCL with 5 years of follow-up from the Population Assessment of Tobacco and Health, a nationally representative longitudinal cohort study of 1856 adults aged 18 years and older in the US. The study sample consisted of individuals with a lifetime history of psychosis. Data were analyzed between January and June 2025. Main Outcomes and Measures: Percentage point (pp) changes in 30-day use of cannabis after RCL compared with control states using difference-in-differences methods. Results: The study sample consisted of 1856 individuals, with a mean age of 36.6 years (SD, 14.8 years) contributing 7465 responses, and was 50.2% White, 58.2% female, and had a 30-day cannabis-use rate of 31.8%. Individuals with psychosis in RCL states significantly increased their 30-day cannabis use by 9.53 pp (95% CI, 3.05-16.00 pp; P = .004), with sensitivity analyses showing significant estimates after retail outlets opened but not before, and no changes in higher frequency use. Conclusions and Relevance: In this study, individuals with psychosis reported a large increase in current cannabis use following legalization and commercialization of cannabis in their state, and by larger amounts than previously reported estimates of the general population. Given how cannabis can negatively affect illness course and health service utilization in individuals with psychosis, these results should be considered by regulators designing policies around taxation, potency, advertising, and health warnings.

Indexed as

CannabisLegislation, DrugMarijuana SmokingMarijuana UsePsychotic DisordersAdolescentAdultFemaleHumansLongitudinal StudiesMaleMiddle AgedUnited StatesYoung Adult

Identifiers

PMID41060643
PMCPMC12509079

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.