Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
38 authors.
Hui YanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-6990-2526
Rui WangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5305-3283
Suryavathi ViswanadhapalliDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-7381-6962
Christian CervantesDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4784-3879
Funan HeDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-4592-4034
Shuai WuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-1818-0831
Azad KhoshDepartment of Molecular Medicine, Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-3267-4280
Weiwei LuoDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-0000-420X
Jingwei WangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-7408-8362
Maria J FernandezDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4820-821X
Uday P PratapDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-2973-0210
Mustafa KhanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5430-7572
Karli HintonDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-0372-3178
Sai Eashan VankamamidiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-6422-2778
Dariela PerezDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0009-0004-9046-8084
Carlos E RiveraDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-9052-557X
Harshita B GuptaDepartment of Biochemistry and Structural Biology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-1003-2658
Fushun ZhangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-0696-8907
Zhenqing YeDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0009-0008-8336-0410
Yidong ChenDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6806-2185
Xiao-Dong LiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4349-6996
Gangadhara R SareddyDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0001-9977-3932
Hong ZanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-2873-7034
Yue LiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0009-0005-3007-8647
Evelien M BunnikDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-4003-3053
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-7053-5009
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3092-1428
Ross M KedlDepartment of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Denver, CO, USA.ORCID 0000-0002-9065-7895
Zhinan YinThe First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0001-6524-8777
Booki MinDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-2151-9413
Diako EbrahimiProgram of Host-Pathogen Interactions, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID 0000-0002-8577-0420
Siyuan ZhengDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-1031-9424
Tyler J CurielDepartment of Microbiology and Immunology, Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.ORCID 0000-0001-6962-9411
Yan XiangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-7633-1629
Ratna K VadlamudiDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-2849-4076
Paolo CasaliDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-8982-5177
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5822-0570
Funding
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3M
The role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell functionR01AI125247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Booki Min · 2017 to 2026
$3.4M
Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzymeR01AI179465 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Diako Ebrahimi · 2024 to 2026
$2.5M
IL-27-producing B cells in the antibody responseR01AI153506 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2021 to 2025
$2.2M
Development of new therapeutic approaches for endometrial cancerR01CA267893 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI VADLAMUDI, RATNA K, VISWANADHAPALLI, SURYAVATHI · 2022 to 2025
$1.7M
B cells as a major source of IL-27 cytokine in antibody responses and anti-viral immunityR21AI135599 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2018 to 2019
B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27-IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 interaction-mediated self-targeting, these cells promoted B cell PD-L1 expression and immune evasion. Mechanistically,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.