ArticleScience advances2025
Mouse olfactory system acts as anemo-detector and anemo-discriminator.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Synaptic Inhibition in the Accessory Olfactory Bulb Regulates Pheromone Location Learning and Memory.FASEB bioAdvances · 2026Article
- Enhanced multisensory integration in the olfactory bulb of the Mexican cavefish.bioRxiv : the preprint server for biology · 2026Article
- Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.Neurophotonics · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
Airflow detection while smelling is a fundamental requirement for olfaction, yet the mechanisms underlying such multimodal processing in the olfactory system remain unknown. We report here that mice can accurately discriminate airflow in the absence of whiskers. Modulated sniffing and refined calcium signaling in the olfactory bulb inhibitory network during olfactory anemo-discriminations confirmed the orthonasal airflow information processing. Genetic perturbation of AMPAR function and optogenetic control bidirectionally shifted the anemo-discrimination learning pace, with contrasting phenotypes observed for odor learning, engagement of inhibitory circuits, and setting the optimal inhibition level for stimulus refinement. Enhanced learning caused by multimodal odor-airflow stimuli at subthreshold levels confirmed the heightened olfactory perception by mechanical stimuli. Our results thus explain the multimodality of olfaction and reveal the unexplored dimensionality of odor perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.