Evidence map›Paper›PMID 41061064›Full record

ArticleScience advances2025

The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in

Lei Wang, Enrique I Oliver, Dario L D'Urso, Bianca Graziano, Laura Bianchi

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Glial overexpression of carbonic anhydrasemicroPublication biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei WangDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-1729-874X
Enrique I OliverDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0009-0004-5893-417X
Dario L D'UrsoDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Bianca GrazianoDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Laura BianchiDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-2615-5345

Funding

Glial ion channels in glia/neurons interactions.R01NS105616 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Laura Bianchi · 2018 to 2026
$3.2M
Glial KCNQ channels.R01NS127146 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Laura Bianchi · 2022 to 2026
$1.9M
Glia in AgingR21AG087451 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIANCHI, LAURA · 2024 to 2025
$422k
NIA NIH HHS R21 AG087451NINDS NIH HHS R01 NS105616NINDS NIH HHS R01 NS127146
6 · The paper itself

Abstract

Aging depends on genetic and environmental factors, but the specific cell types and mechanisms that coordinate aging of the entire organism are not yet fully understood. Glial cells regulate ionic homeostasis, which is essential for neuronal function and survival. Here, we investigated the role of glial ion channel CLH-1, which is a glial pH regulator, in aging. We found that loss of

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsChloride ChannelsLongevityNeurogliaStress, PhysiologicalAgingAnimalsAutophagyForkhead Transcription FactorsHydrogen-Ion ConcentrationNeuronsOxidative StressCaenorhabditis elegans ProteinsChloride Channelsdaf-16 protein, C elegansForkhead Transcription Factors

Identifiers

PMID41061064
PMCPMC12506978

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.