ArticleThe Journal of clinical endocrinology and metabolism2026
Effect of Weight Change on Type 2 Diabetes Risk: A Prospective Study in a Japanese Population.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- African immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment.BMJ open diabetes research & care · 2026Article
- Bodyweight increase since early adulthood as a risk factor for mobility decline: a 7-year longitudinal study of 10,316 Japanese adults aged ≥ 40 years.Archives of public health = Archives belges de sante publique · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAlthough weight reduction has been shown to reduce type 2 diabetes risk, the threshold of weight change, including increase and decrease, associated with the risk remained unclear.
objectiveWe investigated the association between weight change and the risk of type 2 diabetes.
methodsThe participants were 41 539 nondiabetic residents (16 914 men, 24 625 women) in Kochi, Japan, who underwent health examinations between April 2013 and March 2015. The association between 1-year weight change and the risk of type 2 diabetes was assessed using Cox proportional hazards models.
resultsDuring a mean 5.7-year follow-up, 3564 new-onset type 2 diabetes cases were documented. Compared with participants with stable body weight (<1.0% change), those with weight decreases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater showed a lower risk of type 2 diabetes (16% [8%-24%; P < .001]; 25% [15%-34%; P < .001]; and 26% [14%-36%; P < .001], respectively). Conversely, those with weight increases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater showed a higher risk (15% [4%-26%; P = .005], 35% [20%-53%; P < .001], and 51% [29%-76%; P < .001], respectively). These associations persisted among individuals with a body mass index (BMI) of 25 or greater or a 10-kg or greater weight gain since age 20 years. Among individuals with BMI 22 to 25, a weight increase of 3.0% or greater showed a higher risk. No associations were observed in individuals with a BMI of less than 22 or aged 75 or older.
conclusionBoth preventing weight gain and reducing weight are important for lowering the risk of type 2 diabetes in Japanese individuals, particularly among those with a BMI of 22 or greater.
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