ArticleJournal of advanced research2026
A predator-prey interaction between myxobacteria and fungi mediated by outer membrane vesicles.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bacterial extracellular vesicles as players in biofilm dynamics and community interactions.FEMS microbiology reviews · 2026Review
- Laboratory screening and field validation ofFrontiers in microbiology · 2026Article
- Biocontrol of watermelon Fusarium wilt caused byFrontiers in microbiology · 2026Article
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Authors and funding
15 authors.
Funding
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Abstract
introductionOuter membrane vesicles (OMVs) of Gram-negative bacteria mediate diverse functions in natural ecosystems. As a keystone taxon in soil, myxobacteria produce OMVs for cargo packing and microbial predation. However, the roles of OMVs in the interactions of myxobacteria with fungi remain poorly understood.
objectivesThis work aims to clarify the role of outer membrane vesicles in the interaction between myxobacteria and fungi and the regulatory mechanism during the interaction process.
methodsWe found that OMVs play a significant role in the interaction between Myxococcus sp. MP20 and Verticillium dahliae (Vd). We further identified the antifungal metabolites in OMVs and verified the regulatory mechanism of OMVs in the model strain Myxococcus xanthus DK 1622.
resultsWe discover that Myxococcus sp. MP20 uses fungal networks and cotton root exudates for spatial dispersal. MP20 deploys the antifungal metabolites myxothiazole via OMVs to inhibit Vd growth by fusing the OMVs with fungal cells, thus restraining fungal invasion. Containment of myxothiazol within OMVs maintains an effective antifungal concentration on target cells. Furthermore, we demonstrate that the release of OMVs from MP20 was suppressed by iron via a newly discovered ABC transport system. In turn the lower number of OMVs reduced the antifungal behavior of MP20, suggesting that iron acquisition regulates OMV-mediated competition between myxobacteria and fungi. Our findings thus unravel a novel antifungal tactic employed by myxobacteria to suppress fungi prey and control Verticillium wilt, which also provides new insights for understanding predator-prey interactions.
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Registered trials
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