Evidence map›Paper›PMID 41062075›Full record

ArticleJournal of neuroendocrinology2025

GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.

Romana Stark, Jeffrey M Zigman, Zane B Andrews

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Romana StarkMonash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-4264-0060
Jeffrey M ZigmanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Zane B AndrewsMonash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-9097-7944

Funding

Role of the hormone LEAP2 in eating, body weight, blood glucose and survivalR01DK103884 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZIGMAN, JEFFREY M · 2015 to 2023
$3.4M
National Health and Medical Research Council of Australia APP1125960National Health and Medical Research Council of Australia APP1154974National Health and Medical Research Council of Australia APP1160065NIDDK NIH HHS R01 DK103884NIH HHS R01DK103884
6 · The paper itself

Abstract

The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many hormone receptors found in the OB. For instance, recent studies show that selective OB deletion of the receptor for ghrelin and LEAP2 (GHSR; growth hormone secretagogue receptor) increases anxiety-like behaviour and impacts peripheral glucose and energy homeostasis. As GHSR function has been linked to motivated behaviours and spatial navigation, we decided to investigate whether OB-selective GHSR (OB

Indexed as

Exploratory BehaviorFeeding BehaviorMotivationOlfactory BulbReceptors, GhrelinSpatial MemoryAnimalsMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutReceptors, Ghrelinmotivationolfactionspatial navigation

Identifiers

PMID41062075
PMCPMC13091372

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.