Evidence map›Paper›PMID 41063280›Full record

ArticleArthritis research & therapy2025

Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease.

Chenghua Weng, Enzhuo Liu, Hui Zheng, Zhenke Wen, Yiting Ji, Gang Wang, Lei Zhang, Rongfang Hu, Lei Shen, Zhichun Liu

Abstract read
In one paragraph

Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenghua Weng *Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China.ORCID 0000-0001-7253-7745
Enzhuo Liu *Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China.
Hui ZhengJiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.
Zhenke WenJiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.
Yiting JiDepartment of Obstetrics and Gynecology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, 215009, China.
Gang WangDepartment of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China.
Lei ZhangDepartment of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China.
Rongfang HuDepartment of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China.
Lei ShenDepartment of Nephrology, The First Affiliated Hospital of Soochow University, Pinghai Road No. 899, Suzhou, Jiangsu, 215008, P.R. China. shenlei2073@163.com.
Zhichun LiuDepartment of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu, 215004, P.R. China. zcliurheu@suda.edu.cn.ORCID 0000-0001-6170-9601

Funding

Jiangsu Provincial Health Key Research and Development Project ZD2022032Suzhou Medical and Health Science Technology Innovation Project SKY2022146Suzhou Science and Technology Bureau Clinical Trial Institution Capability Improvement Project SLT2023035
6 · The paper itself

Abstract

backgroundAnti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis (MDA5

methodsWe performed scRNA-seq of peripheral blood mononuclear cells (PBMCs) from MDA5

resultsThe proportion of CD14

conclusionsThis study demonstrates that antiviral response plays an important role in the pathogenesis of MDA5

Indexed as

AutoantibodiesDermatomyositisInterferon-Induced Helicase, IFIH1Lung Diseases, InterstitialSingle-Cell AnalysisAdultAgedDisease ProgressionFemaleHumansLeukocytes, MononuclearMaleMiddle AgedAutoantibodiesIFIH1 protein, humanInterferon-Induced Helicase, IFIH1DermatomyositisMDA5PBMCRPILDScRNA-seq

Identifiers

PMID41063280
PMCPMC12506285

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.