Evidence map›Paper›PMID 41064262›Full record

ArticleFrontiers in veterinary science2025

Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.

Baili Lu, Jiayu He, Shirou Pan, Junhao Wei, Bingxin Li, Nan Cao, Yunmao Huang, Yunbo Tian, Ngai Cheong, Ying Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Baili Lu *College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Jiayu He *College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Shirou PanCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Junhao WeiFaculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Bingxin LiCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Nan CaoCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Yunmao HuangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Yunbo TianCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Ngai CheongFaculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Ying ChenSchool of Health Economics and Management, Nanjing University of Chinese Medicine, Nanjing, China.
Danning XuCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Wanyan LiCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atractylodes macrocephala Koidz. (AMK) and its purified polysaccharide fraction (PAMK) are known for their antioxidant, anti-inflammatory, and hepatoprotective properties, showing potential benefits for poultry liver health. This study simulated hepatic oxidative stress in late-laying hens, a physiological stage characterized by increased metabolic demands and reactive oxygen species (ROS) generation, without exogenous hepatotoxic agents. Hens were randomly assigned to three groups: control (basal diet), AMK (basal diet + 15 g/kg AMK), and PAMK (basal diet + 400 mg/kg PAMK). Both AMK and PAMK significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities compared to control. Notably, PAMK showed superior efficacy, decreasing malondialdehyde (MDA) levels by 35.29% vs. 32.87% in AMK, and more effectively increasing antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Histopathological analysis revealed better-preserved liver structure and less inflammatory infiltration in PAMK-fed hens. Mechanistically, both treatments upregulated Nrf2 and downstream antioxidant genes, with stronger activation observed in the PAMK group.

Indexed as

apoptosisbroiler breedersoxidative stressPAMKtraditional Chinese medicine

Identifiers

PMID41064262
PMCPMC12502850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.