Evidence map›Paper›PMID 41065019›Full record

ArticleHeadache2026

Building a national headache medicine research network: The BE WELL with Migraine Champion Providers Network™.

Rebecca Erwin Wells, Junelyn Floyd, Hannah O'Brien, Nicole Tamol, Caroline Oliver, Camden Nelson, Joshua Phillips, Paige M Estave, Shivani Vaidya, Brian Moore and 10 more

Abstract read
In one paragraph

Article in Headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rebecca Erwin WellsWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-9860-3699
Junelyn FloydWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Hannah O'BrienWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Nicole TamolWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Caroline OliverWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Camden NelsonLewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0009-0003-3420-7958
Joshua PhillipsCambridge Health Alliance, Boston, Massachusetts, USA.
Paige M EstaveWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Shivani VaidyaWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Brian MooreWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Katherine HamiltonMedstar Georgetown University Hospital, Washington, DC, USA.
Ellie AdamWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Nathaniel O'ConnellWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Justin B MooreWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-4059-0538
Richard B LiptonAlbert Einstein College of Medicine, New York, New York, USA.
Timothy T HouleMassachusetts General Hospital, Boston, Massachusetts, USA.
Zev Schuman-OlivierCambridge Health Alliance, Boston, Massachusetts, USA.ORCID 0000-0001-9216-2039
Paula GardinerCambridge Health Alliance, Boston, Massachusetts, USA.
Scott W PowersCincinnati Children's Hospital, Cincinnati, Ohio, USA.
BE WELL with Migraine Champion Providers Network™

Funding

CTSA UM1 Program at Wake ForestUM1TR004929 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamy D Ard, KRISTIE L FOLEY · 2024 to 2026
$11.9M
Online TEAM Migraine: Online Techniques and Education Aimed to Manage MigraineR01AT011502 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Rebecca Erwin Wells · 2022 to 2026
$3.2M
NCATS NIH HHS UM1 TR004929NCCIH NIH HHS R01 AT011502NIH HHS R01AT011502NIH HHS UM1TR004929
6 · The paper itself

Abstract

objectiveOur objective was to develop and assess the effectiveness of a national network of clinicians referring adults with migraine for a remotely delivered clinical trial.

backgroundA national practice-based research network in Headache Medicine would facilitate referrals into clinical trials. Given our unique, entirely virtual study, we established a national network of health care professionals to identify potential participants.

methodsThe BE WELL with Migraine Champion Providers Network™ began to support clinician referrals across the United States into a remotely conducted clinical trial evaluating the efficacy of a nondrug virtual group intervention. Participant trial recruitment includes community outreach and clinician referrals, then potential participants complete a multi-step eligibility process. The primary study team obtains informed consent and collects all study outcomes. Clinicians interested in referring patients register for the Network via a Research Electronic Data Capture survey. The ongoing clinical trial allows for recruitment of trial participants and network members through 2026. We analyzed Network survey results through February 25, 2025, with descriptive statistics and qualitative analyses. We compared participant progression through eligibility assessment between clinician referral and community outreach.

resultsThe BE WELL with Migraine Champion Providers Network™ includes 46 clinicians across the United States through February 2025, and most (89%) of them are headache specialists. Although many have previously served as trial principal investigator (PI) (54%) or recruited (72%) for a trial in the past, 28% are recruiting for a clinical trial for the first time. Top motivating factors for Network participation included nonpharmacological option (n = 12), research contribution (n = 11), potential for patient improvement (n = 11), and working with PI (n = 9). To date, 905 participants completed the initial online screener, with 5% (n = 41) from clinician referrals and 95% (n = 864) from community recruitment. Of those, 12.3% (n = 107) were eligible to continue and consented and completed the virtual interview. After the interview, 65 participants progressed to the headache log run-in period and then were randomized/eligible for randomization (six from referrals, 59 from community). Of the original participants from clinician referrals who completed the online screener, 14.6% (six of 41) were randomized/eligible for randomization, compared to 6.8% (59 of 864) recruited via community. Once consented, 100% (six of six) of Network-referred patients progressed to randomization/eligibility for randomization versus only 58% (59 of 101) from community recruitment.

conclusionThe BE WELL with Migraine Champion Providers Network™ models the development and implementation of a national clinician referring network that can help accomplish the field's research priorities. Although growth and implementation of a national network takes time, our results demonstrate the yield of appropriate referrals eligible for randomization was more than double community recruitment.

Indexed as

Biomedical ResearchClinical Trials as TopicMigraine DisordersPatient SelectionReferral and ConsultationAdultFemaleHumansMaleMiddle AgedUnited Statesclinical trialmind–body interventionnonpharmacological treatmentsonline virtual studyreferral networktelemedicine

Identifiers

PMID41065019
PMCPMC12766894

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.