Evidence map›Paper›PMID 41065178›Full record

ArticleACS infectious diseases2025

Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against

Alexandria A Oviatt, Jessica A Collins, Chelsea A Mann, Jianzhong Huang, Karen Mattern, Pan F Chan, Neil Osheroff

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. In Vitro Activity of Zoliflodacin AgainstAntibiotics (Basel, Switzerland) · 2026
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandria A OviattDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-4629-7642
Jessica A CollinsDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-4077-1016
Chelsea A MannDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Jianzhong HuangInfectious Diseases Research, GSK, Collegeville, Pennsylvania 19426, United States.
Karen MatternInfectious Diseases Research, GSK, Collegeville, Pennsylvania 19426, United States.
Pan F ChanInfectious Diseases Research, Vaccines Research and Development Infectious Diseases Research, GSK, Collegeville, Pennsylvania 19426, United States.ORCID 0009-0000-0789-632X
Neil OsheroffDepartments of Biochemistry and Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-2550-4884

Funding

BIOCHEMICAL &CHEMICAL TRAINING FOR CANCER RESEARCHT32CA009582 · NCI · VANDERBILT UNIVERSITY · PI David K Cortez · 1987 to 2026
$8.8M
Mechanistic Studies of Gyrase/Topoisomerase IV-Targeted AntibacterialsR01AI170546 · NIAID · VANDERBILT UNIVERSITY · PI NEIL OSHEROFF · 2023 to 2026
$2.7M
Mechanistic Studies of Type II Topoisomerases and Topoisomerase-Targeted AgentsR01GM126363 · NIGMS · VANDERBILT UNIVERSITY · PI OSHEROFF, NEIL · 2018 to 2025
$2.6M
Overcoming fluoroquinolone resistance in Neisseria gonorrhoeaeF31AI149863 · NIAID · VANDERBILT UNIVERSITY · PI OVIATT, ALEXANDRIA · 2020 to 2021
$58k
Actions of spiropyrimidinetriones against bacterial type II topoisomerasesF31AI174684 · NIAID · VANDERBILT UNIVERSITY · PI COLLINS, JESSICA A · 2023 to 2023
$31k
BLRD VA I01 BX002198NCI NIH HHS T32 CA009582NIAID NIH HHS F31 AI149863NIAID NIH HHS F31 AI174684NIAID NIH HHS R01 AI170546NIGMS NIH HHS R01 GM126363
6 · The paper itself

Abstract

Gonorrhea, a sexually transmitted infection caused by

Indexed as

AcenaphthenesAnti-Bacterial AgentsDNA GyraseDNA Topoisomerase IVHeterocyclic Compounds, 3-RingNeisseria gonorrhoeaeTopoisomerase II InhibitorsDrug Resistance, BacterialGonorrheaHumansMicrobial Sensitivity TestsAcenaphthenesAnti-Bacterial AgentsDNA GyraseDNA Topoisomerase IVgepotidacinHeterocyclic Compounds, 3-RingTopoisomerase II InhibitorsDNA cleavageDNA supercoiling/decatenationgepotidacingyraseNeisseria gonorrhoeaetopoisomerase IV

Identifiers

PMID41065178
PMCPMC12624743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.