Evidence map›Paper›PMID 41068024›Full record

ReviewSeminars in nephrology2026

Neuroimmune Regulation for Acute Kidney Injury Therapy: Insights Along the Path From Bench to Bedside.

William T Nash, Mark D Okusa

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William T NashCenter for Immunity, Inflammation, and Regenerative Medicine (CIIR), Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA.
Mark D OkusaDepartment of Medicine, University of Virginia, Charlottesville, VA. Electronic address: mdo7y@virginia.edu.

Funding

Neuroimmune Regulation of Acute Kidney InjuryR01DK123248 · NIDDK · UNIVERSITY OF VIRGINIA · PI Mark Douglas Okusa · 2019 to 2026
$3.3M
Ultrasound for Non-Invasive Prevention of Acute Kidney InjuryR01DK105133 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2015 to 2019
$2.4M
Proof of concept and feasibility in humans for pulsed ultrasound treatment to reduce inflammation and risk of AKIR01DK137937 · NIDDK · UNIVERSITY OF VIRGINIA · PI Mark Douglas Okusa, Mitchell H. Rosner · 2024 to 2026
$942k
NIDDK NIH HHS R01 DK105133NIDDK NIH HHS R01 DK123248NIDDK NIH HHS R01 DK137937
6 · The paper itself

Abstract

Over the past 25 years, neuroimmune regulation has emerged as a compelling approach to the prevention and treatment of acute kidney injury. Vagus nerve stimulation through the cholinergic anti-inflammatory pathway can suppress inflammatory responses and demonstrate therapeutic potential in both animal disease models and a variety of human inflammatory conditions. The mechanisms underlying this neuroimmune-regulated protection are complex, but research undertaken since 2000 has significantly advanced our understanding of the key elements involved. This research has also yielded intriguing results and unexpected observations. In this review, we highlight current insights into vagus nerve-mediated neuroimmune regulation, areas of ongoing uncertainty, and promising directions for therapeutic modulation in AKI.

Indexed as

Acute Kidney InjuryNeuroimmunomodulationVagus NerveVagus Nerve StimulationAnimalsHumansAKIanti-inflammationcholinergic anti-inflammatory pathwayinflammationvagus

Identifiers

PMID41068024
PMCPMC12626138

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.