ArticleCancer causes & control : CCC2025
Use of healthcare services and prescription medication prior to sarcoma diagnosis in children, adolescents, and young adults in 1997-2020: a population-based cohort study.
Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patients' experiences of the path to sarcoma diagnosis: a qualitative systematic review and thematic synthesis.BMJ open · 2026Pooled it
- Diagnostic Intervals in Children, Adolescents and Young Adults with Primary Bone Sarcoma: A Systematic Review.Cancers · 2026Review
- International variation in child healthcare practices and implications for childhood cancer diagnosis: a scoping review and cross-country clinician survey.European journal of pediatrics · 2026Article
- Increasing survival disparity between children, adolescents, and young adults with osteosarcoma or Ewing sarcoma of bone from 1990 to 2024: a population-based cohort study.Acta oncologica (Stockholm, Sweden) · 2026Article
- Classification of Inpatient and Outpatient Contacts in the Danish National Patient Register: Epidemiological Implications and Future Directions.Clinical epidemiology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeSarcomas are among the leading causes of cancer death in children, adolescents, and young adults and survival has not been substantially improved for decades. Reducing the diagnostic interval could contribute meaningfully to increased survival at a low- cost. This study provided much-needed knowledge of the prediagnostic patient trajectories to direct future clinical efforts.
methodsThis population-based study examined the use of healthcare services in the two years preceding diagnosis in 1524 children, adolescents, and young adults with sarcoma compared to the background population, based on Danish national register data from 1997 to 2020.
resultsSarcoma patients were more likely than the background population to have contacts in the primary healthcare sector, hospital outpatient clinics, and emergency rooms, and to fill prescriptions for pain- and antimicrobial medication for up to 24 consecutive months before diagnosis. Patients with metastatic sarcoma at the time of diagnosis were more likely than non-metastatic patients to use healthcare services in the last 2-4 months prior to diagnosis.
conclusionReducing the diagnostic interval in early-life sarcomas should be explored as a low-cost complement to new, advanced treatments to improve survival. Efforts should focus on improving the selection of CAYA with musculoskeletal symptoms for early referral and a better understanding of the diagnostic pathway within the secondary healthcare system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.