ArticleBMC cardiovascular disorders2025
Triglyceride-glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride-glucose strata.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- TyG Index and Frailty as Composite Biomarkers of Cardiometabolic Risk and Mortality Across CKM Stages 0-3.Metabolites · 2026Article
- Association between the triglyceride-glucose index and subclinical atherosclerosis in asymptomatic adults: a large cross-sectional study of a health check-up population.Frontiers in cardiovascular medicine · 2026Article
- Association of the Triglyceride Glucose Index and Epicardial Adipose Tissue with Type 2 Diabetes Mellitus Complicated by Coronary Atherosclerotic Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
aimsAtherosclerosis is established as a chronic inflammatory disease, yet the potential mediating role of glucose and lipid metabolism in inflammation-driven atherogenesis has not been fully elucidated. Herein, we investigated the association between low-grade inflammation and atherosclerosis, with joint effects of the triglyceride–glucose (TyG) index. METHODS AND
resultsWe included data from two cohorts: the UK Biobank (UKB), a prospective study, and the Huinan cohort in Shanghai, a cross-sectional study, both with complete data from duplex ultrasounds for carotid intima-media thickness and circulating blood cell counts We identified the function of TyG as an inflammatory index and compared the risk related to atherosclerosis among different TyG levels. In total, 33,123 UKB participants (mean [SD] age 55.24 [7.58] years; 51.42% women) and 3,440 Huinan participants (mean [SD] age 70.32 [6.63] years; 58.26% women) showed increased cIMT along with higher inflammation markers including INFLA-score 0.76 [8.65], and white blood cell (WBC) count (6.58 [1.76]), after adjusting for covariates. High TyG (over the median) was associated with a higher low-grade circulating inflammation-related estimate for cIMT compared to low TyG. In UKB cohort, mediation analysis revealed that the TyG index mediated 23.36%, 10.25%, 26.30%, and 12.19% of the effects exerted by the INFLA-score, CRP, WBC count, and lymphocyte count on cIMT, respectively.
conclusionsThese findings suggested that circulating inflammation status can exacerbate both subclinical and clinical atherosclerosis, with joint effects from the TyG index. This highlights the role of a balance between metabolic and inflammatory factors in atherosclerosis.
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