ArticleNutrition & metabolism2025
The association between dietary consumption of amino acids and the risk of non-alcoholic fatty liver disease: a case-control study.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Amino Acid Metabolism in Chronic Liver Disease: from Pathogenic Driver to Therapeutic Target.International journal of biological sciences · 2026Review
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12 authors.
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Abstract
backgroundFew studies, with inconsistent results, have been conducted to examine the effect of protein and amino acid consumption on non-alcoholic fatty liver disease (NAFLD). Therefore, this study aimed to assess the relationship between dietary intake of amino acids or groups of amino acids and the risk of NAFLD.
methodsThis case-control study included 171 participants with NAFLD and 730 controls from Tehran, Iran. A validated Food frequency questionnaire (FFQ) with 168 items, was used to evaluate dietary information. Odds ratios (ORs) and corresponding confidence intervals (CIs) were calculated by regression models, adjusted for potential confounders including age, sex, body mass index (BMI), smoking status, physical activity, history of diabetes mellitus, and total energy intake.
resultsThe mean ± standard deviation (SD) age of participants was 43.26 ± 13.9 years. Intake of total protein and all amino acids was significantly higher in patients with NAFLD than in the control group (P < 0.001). Increased risk of developing NAFLD compared to the reference quartile was observed in the highest quartiles of dietary isoleucine (OR, 4.72; 95%CI, 1.57-14.19), tyrosine (OR, 5.11, 95%CI, 1.73-15.05), threonine (OR, 3.47; 95%CI, 1.16-10.33), and valine (OR, 4.51; 95%CI, 1.45-14.02) intake. Subgroup analysis by sex revealed that in the females, the OR for NAFLD were 0.36 (95%CI, 0.13-0.98) among those with the highest intake of non-essential amino acids, and 2.78 (95%CI, 1.02-7.50) among those with the highest intake of essential amino acids compared to those in the first quartile. However, there was no significant trend among male cases.
conclusionConsumption of specific amino acids might be associated with odds of NAFLD.
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